Personalized medicine experiment details diabetes development


Former Executive Editor, Harvard Health

The term “personalized medicine” is still something of an abstract idea. In an audacious experiment, Stanford molecular geneticist Michael Snyder gave it a face—his own—and showed what it can do.

Snyder and a large team of colleagues first sequenced his DNA, revealing his complete genetic library. This information showed that Snyder was at increased risk for high cholesterol, coronary artery disease, basal cell carcinoma (a type of skin cancer), and type 2 diabetes. Next, they measured thousands of biological markers in Snyder’s blood every few weeks for two years.

During the average checkup or workup for an illness, a doctor will look at maybe 20 chemical or biological markers. This simple snapshot can be helpful. What Snyder and his colleagues did was akin to taking a 3-D movie of his inner workings on a molecular level to observe how genes, the molecules that read and decode them (RNA), the proteins they make, and other substances work together during health and how they respond to illness.

The team saw how Snyder’s body responded to a cold at the very beginning of the study. Midway through, they watched as molecular changes wrought by a respiratory infection tipped him into full-blown diabetes. The work was published in the journal Cell.

This intensive approach to health monitoring isn’t coming to your doctor’s office any time soon. It’s an expensive process that takes a lot of time and technology, and the information it generates would overwhelm most people and their doctors. But it offers new ways to identify diseases and their triggers early, and offers a peek at how personalized medicine might someday work.

Diabetes connection

The study’s eyewitness account of the development of diabetes really caught my attention. Just before the study’s midpoint, Snyder was infected by the respiratory syncytial virus, which affects the lungs. About two weeks later, measures of his blood sugar regulation stopped looking normal. Then his blood sugar level began increasing. Three months later, Snyder was diagnosed with type 2 diabetes.

The lung infection prompted Snyder’s body to make various antibodies. That’s a healthy response to an infection. But it also made autoantibodies—antibodies that attacked his own proteins. One of the autoantibodies targeted a receptor on the surface of cells that latches onto insulin, a hormone that’s needed to usher glucose (blood sugar) into cells. Interfering with that receptor makes it hard for cells to absorb sugar from the bloodstream, a hallmark of diabetes.

I was diagnosed with diabetes six years ago, right after having a severe and persistent infection. The news was an absolute shock—I’m thin, active, eat a pretty healthy diet, and there isn’t any diabetes in my family.

I’ve long thought that the infection caused, or at least triggered, my diabetes. There hasn’t been much in the medical literature—until now—to back up my suspicion. The work by Michael Snyder and his colleagues won’t do anything to help me control my blood sugar, but it does help take some of the mystery out of why I’m living with this condition.


  1. jojolendir

    great article…i have to admit

  2. nando eriawan

    it’s so dangerous if we get lung infection. just because of it, many illness we get. I hope I can keep good my health in order not got it

  3. Aamir

    An interesting discussion is worth comment. I do think that you need to publish more about this issue, it might not be a taboo subject but usually folks don’t talk about such subjects. To the next! Best wishes!!

  4. bestdiet

    There is no cure for diabetes, but it can be managed.You can manage it by taking good care of yourself. If you take good care of yourself, you can live a long healthy life with diabetes.

  5. Daniel

    I wonder what kind of point this makes for trying to take care of our immune systems through the means of vitamin/minerals and antioxidants.

    If the trigger seems to come from an infection and autoantibodies created along with antibodies to fight the infection, then we need to try fighting what caused the infection to spread, namely an immune system that was susceptible.

    Interesting article!

  6. Mattiew

    Yep, it’s what a useful article, I hope there is an explanation about diabetes and diet for diabetes, I mean, hot by changing dietary habits can help to reduce the negative effect of diabetes

  7. Ann M.

    Fascinating! I know there’s long been an association between infections and diabetes, but I’ve never heard of scientists actually capturing the trigger in real time. (There’s also an association with infections and certain mental illnesses — such as schizophrenia.) Will be interesting to see how this research evolves.

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