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Combination of a cholesterol-lowering statin and ezetimibe lowers risk of a heart attack or stroke
- By: Gregory Curfman, MD, Assistant Professor of Medicine, Former Editor-in-Chief, Harvard Health Publishing
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
I am curious if ezetimibe (Vytorin) works the same way plant sterols or stanols work. Products such as Benecol also work by blocking cholesterol absorption in the intestines.
my doctor took me off zetia and increased the statin level. Result: my LDL went higher, noticeably. With this article, I am inclined to go back onto Zetia….
my total cholesterol yesterday was 97, with LDL of 15 and HDL of 75. I take 15 mg of Crestor and 2000 mg of Niaspan an I am 63. my ct score was 382 and have family history of heart disease. I am having some digestion issues and general tiredness . any connection? Can LDL be too low.
Lowering LDL to such extreme levels seems off the mark, especially since there are an unknown number of individuals like me, age 69, with a lifetime of extreme LDL (over 500mg/dl for the last eight years) and yet no plaque at all by EBCT and no family history of CVD going back four generations. Nobody knows why, and worse yet, almost nobody seems to want to find out.
A two percent reduction over seven years means for an individual that the annualized risk reduction is 0.28 percent. This may sound good to epidemiologists, but for an individual that isn’t even close to considering. It is between naive and dishonest to think that this new drug has no increased risk of side-effects.
Helpful and informative. It is good to have latest developments.
Can someone tell me if the medication Ezetimibe is the same as Zetia (10mg) ??
Very good article, I have a question, I am one of those people who cannot take statin drugs due to muscle soreness & weakness so I take Niaspan, would ezetimibe be beneficial for those of us who have issues with the statin drugs?
PCSK-9 inhibitors may be available in the next few years. There are also on-going trials.
Very informative,and absorbing article.Also very helpful for people who have heart problems,but the most important thing is we are in touch with the new advances in the medical world.Thank you Harvard Education.
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