Weight loss medications Archive

Obesity is a common, chronic disease that can harm the heart. The powerful weight-loss medications known as GLP-1s, semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), are now recommended as first-line therapy for eligible people, according to the American College of Cardiology. People using these drugs should work with a dietitian or nutritionist who can help them create a personalized eating plan that ensures they're getting enough nutrients while minimizing common side effects.

A 2025 research review found that healthy adults who paired exercise with time-restricted eating lost more fat than participants who didn't restrict their eating window-without sacrificing lean muscle tissue.

A randomized controlled trial published in 2025 found that people who followed a 4:3 intermittent fasting plan for one year, eating only 20% of their usual calories on three fasting days per week, lost more weight than people who were on a calorie-restricted diet.

In a 2024 study of more than 183,000 middle-aged healthy people followed for 13 years, those who closely followed a plant-based diet had lower risks of developing blood clots in the legs or lungs, even if their genes made them more likely to get the blood clots.

Some people may feel like it's pointless to exercise if they're not losing weight as a result. But there are many reasons to exercise beyond weight loss. Regular exercise has a long list of health benefits, including an energy boost, better sleep, and reduced risks for addictive behaviors as well as many chronic diseases such as heart disease, strokes, many cancers, dementia (including Alzheimer's disease), diabetes, depression, anxiety, pneumonia, osteoporosis, and kidney problems.

As estrogen levels drop, women's bodies store more fat around the abdomen, fueling a weight shift to the belly. Women can counter this by ramping up protein intake and doing strength training to maintain muscle mass and metabolism.

The FDA has approved three GLP-1 receptor agonist drugs for weight loss. The drugs not only lower blood sugar and weight, but also quiet inflammation, stimulate the production of antioxidants, help repair damaged DNA, and slow the aging of the body's cells. Evidence suggests that among people who use the drugs for diabetes and obesity, the drugs reduce the risks of kidney disease progression, heart attack, death from heart disease, death from COVID-19, and death from all causes by 15% to 35%.