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What to do when your blood pressure won’t go down

Doctors recommend several strategies to lower resistant hypertension. One strategy is discontinuing medications that may be contributing to high blood pressure, such as nonsteroidal anti-inflammatory drugs (NSAIDs), decongestants, certain antidepressants, and corticosteroids. Another strategy is treating underlying conditions that can boost blood pressure, such as sleep apnea. Other ways to lower stubbornly high blood pressure include getting lots of aerobic exercise, eating a plant-based diet that’s low in salt, getting at least seven hours of sleep per night, limiting alcohol, avoiding smoking, and maintaining a healthy weight.

What’s new in diabetes drugs

Two classes of diabetes drugs—GLP-1 receptor agonists and SGLT-2 inhibitors—have received much attention lately. They not only lower blood sugar, they also help with weight reduction and may lower the risk of heart attack, stroke, and chronic kidney disease. The drugs can be taken as daily oral tablets or in some cases weekly injections, both of which are preferable over daily insulin shots.

Over-the-counter drugs that can boost blood pressure

People with high blood pressure should avoid certain popular over-the-counter drugs used to treat cold and flu symptoms and pain. The problematic products are those that contain decongestants such as oxymetazoline, pseudoephedrine, and phenylephrine; and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen sodium. Because drugstores contain an overwhelming number of products that feature those drugs, people should ask their pharmacist to recommend a product.

Breakthrough: AI and better medicines

Many diseases occur because of defects in particular proteins—the workhorses of every cell. But developing a drug that targets a defective protein requires knowing that protein's shape. Protein shapes have always been difficult to predict. Then in July 2021, a company called DeepMind reported that its software predicted the structures for 98% of human proteins. By the end of 2021, DeepMind says it will publish the shape of 50% of the 280 million nonhuman proteins, up from 0.01%. These breakthroughs are expected to lead to new medicines.

Sore throat soothers

Most sore throats are caused by non-life-threatening conditions or certain behaviors. But sometimes a sore throat may be an indication of COVID-19. One should call the doctor if experiencing difficulty swallowing, shortness of breath, a high fever, or a cough that produces blood. Ways to relieve sore throat pain include staying hydrated, using over-the-counter painkillers, drinking warm liquids, using cough drops, using a spray or lozenge that contains an oral anesthetic to numb the throat, and treating an underlying condition causing sore throat pain.

Less may be more when treating urinary tract infections

Researchers found that treating urinary tract infections with antibiotics for seven days was just as effective as treatment lasting 14 days. The shorter duration also can reduce the risk of medication side effects like diarrhea and nausea.

Is your medication making you lightheaded?

Many medications can cause lightheadedness, such as drugs to treat depression, high blood pressure, or bladder problems. It’s important to learn about a medication’s potential side effects and be on high alert if lightheadedness is a possibility. A person can jot down the day and time a drug is taken as well as any side effects that follow; those details can help a doctor determine if changes in medicines are required. Someone who continues to feel lightheaded after about a week should report it to the doctor.

Drug therapy needs time to treat heart-related chest pain

Chest pain with exertion affects about one-quarter of people with stable coronary artery disease. A 2021 study found that these individuals can often eliminate their symptoms by following conservative drug therapy, without needing a stent or bypass surgery.

Why are mRNA vaccines so exciting?

The  first vaccines approved in the US to prevent COVID-19 were an entirely new type: mRNA vaccines. Over the past year, they've proven unusually effective and safe. How do mRNA vaccines differ from traditional vaccines, and what makes them so exciting?

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