Alzheimer's Disease Archive

Research we're watching

Although hormone therapy was once thought to help preserve cognitive function after menopause, there is mounting evidence to the contrary, including a recent report from the Kuopio Osteoporosis Risk Factor and Prevention Study.

Researchers in that project sent questionnaires to all women ages 47 to 56 who lived in the Finnish province of Kuopio in 1987. The women completed questionnaires every five years, providing information about their lifestyles, medication use, and illnesses. The researchers checked the information in the questionnaires against prescription registries and medical records up to 2009.

Research we're watching

Aging brains often show signs of microscopic strokes, which result from damage to tiny blood vessels within the brain. Those that occur in the brain's outermost layer — called cortical cerebral microinfarcts (CMIs) — usually don't cause any symptoms. But they are more common in autopsies of people diagnosed with dementia. Now, new research suggests a link between blood markers for early heart disease and CMIs.

The study, published online Feb. 6, 2017, by JAMA Neurology, included 243 people who attended a memory clinic. All had brain scans to check for CMIs and blood tests that measured two substances associated with early signs of heart damage. People who had CMIs (nearly 29% of the participants) were much more likely to have heart disease than those who didn't have CMIs. Higher levels of both substances associated with heart damage were also linked to CMIs — even when the researchers left out people who already had obvious symptoms of heart disease.

In the journals

A study of almost 31,000 men whose prostate cancer had not spread found that the use of androgen deprivation therapy (ADT) was not associated with a higher risk of Alzheimer's disease. This counters previous studies that suggested a possible link. The results were published in the January 2017 Journal of Clinical Oncology.

ADT is used in prostate cancer treatment to eliminate testosterone, since the hormone can fuel the disease. Testosterone levels also are traditionally lower in men with Alzheimer's compared with control groups, which suggests there may be a connection between lowering testosterone and an increased risk of Alzheimer's. Previous studies that have explored this connection found that a low testosterone level caused by ADT was associated with a higher probability of developing Alzheimer's. But these studies often covered a shorter time period — for instance, one year or less — and it is doubtful that men were on ADT long enough to cause Alzheimer's.

In the journals

Previous research has suggested that slow walking speed might predict cognitive decline, but a recent study suggests how you walk also may provide clues. The results were published online Nov. 19, 2016, by the Journal of Alzheimer's Disease.

Researchers examined medical records of more than 3,400 people ages 70 to 89 who had completed both a neurological examination and gait analysis to measure walking movements like stride length, step count, cadence, stance time, and arm swings.

Research we're watching

Mentally engaging activities have been long been promoted for staving off dementia, but there isn't a lot of information about whether doing them late in life is effective in preventing mild cognitive impairment (MCI), a precursor of dementia. To help fill that gap, researchers from the Mayo Clinic Study of Aging followed 956 men and 973 women ages 70 or older who had normal scores on mental function tests. The participants answered periodic questionnaires detailing whether and how often they read books, did craft projects, used a computer, played games, and engaged in social activities like going out to movies and plays. They also underwent neurologic exams and completed tests to assess mental function. Over an average of four years, 456 participants developed mild cognitive impairment.

When the researchers analyzed the results, they found that playing games, doing craft projects, using a computer, and engaging in social activities were associated with a significant reduction in the risk of developing mild cognitive impairment.

How a healthy lifestyle can make a difference in Alzheimer’s prevention.

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of two types of protein in the brain: tangles (tau) and plaques (amyloid-beta). Eventually, Alzheimer's kills brain cells and takes people's lives.

Alzheimer’s causes

What causes Alzheimer's? We still aren't sure. "For 1% of all cases, there are three genes that determine definitively whether or not you will have Alzheimer's, and all three relate to amyloid-beta production, which in these cases is likely the cause of Alzheimer's," says Dr. Gad Marshall, associate medical director of clinical trials at the Center for Alzheimer Research and Treatment at Harvard-affiliated Brigham and Women's Hospital. "For the other 99%, amyloid and tau are closely associated with Alzheimer's, but many things may contribute to the development of symptoms, such as inflammation in the brain, vascular risk factors, and lifestyle."

Vascular dementia is a less prevalent type of memory loss that nonetheless affects many older men.

 Image: Mike Watson Images/Thinkstock

While Alzheimer's disease continues to be the most recognized type of dementia, older men should also be mindful about the second most common: vascular dementia.

In vascular dementia, memory problems result from damage to large and small blood vessels in the brain. It develops when cholesterol-clogged blood vessels can't deliver enough oxygen to the brain. Small blockages deprive some brain cells of oxygen, which causes a series of small strokes that kill brain cells. This can lead to episodes of confusion, slurred speech, and problems thinking or remembering.

Older adults who report feeling lonely had a greater risk of testing positive for high amyloid levels in the brain, a marker of Alzheimer’s disease, according to research from the Harvard Aging Brain Study.

Poor blood flow in the brain can chip away at thinking skills.

Image: RootsBeforeBranches/Thinkstock

Just like in the rest of your body, advancing years can take a toll on your brain function. Much of this slowing down is predictable and can be chalked up to normal aging. However, when thinking skills become increasingly fuzzy and forgetfulness gets to be a way of life, an early form of dementia known as mild cognitive impairment may be setting in (see "Normal aging vs. mild cognitive impairment").

Often, the first reaction is to attribute these changes to the beginning of Alzheimer's disease. But blood flow problems may be to blame, as well. "An estimated one-third of all cases of dementia, including those identified as Alzheimer's, can be attributed to vascular factors," says Dr. Albert Hofman, chair of the department of epidemiology at the Harvard T.H. Chan School of Public Health.

A class of drugs commonly used in over-the-counter and prescription drugs to treat such problems as insomnia, diarrhea, high blood pressure, depression, and urinary incontinence may be linked to cognitive impairment. Scientists believe the drugs block the neurotransmitter acetylcholine that helps process information, which scientists believe is responsible for the effect.