Recent Blog Articles

Can we prevent depression in older adults by treating insomnia?

Want to try veganism? Here's how to get started

Vitamin B6 flies under the radar: Are you getting enough?

The formula shortage is hurting families: What parents should know and do

Gyn Care 101: What to know about seeing a gynecologist

Swimming lessons save lives: What parents should know

Strong legs help power summer activities: Hiking, biking, swimming, and more

What is a successful mindset for weight loss maintenance?

French fries versus almonds: Calorie for calorie, which comes out on top?

Summer camp 2022: Having fun and staying safe
What causes depression?
Onset of depression more complex than a brain chemical imbalance
It's often said that depression results from a chemical imbalance, but that figure of speech doesn't capture how complex the disease is. Research suggests that depression doesn't spring from simply having too much or too little of certain brain chemicals. Rather, there are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, and stressful life events. It's believed that several of these forces interact to bring on depression.
To be sure, chemicals are involved in this process, but it is not a simple matter of one chemical being too low and another too high. Rather, many chemicals are involved, working both inside and outside nerve cells. There are millions, even billions, of chemical reactions that make up the dynamic system that is responsible for your mood, perceptions, and how you experience life.
To continue reading this article, you must log in.
Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School.
- Research health conditions
- Check your symptoms
- Prepare for a doctor's visit or test
- Find the best treatments and procedures for you
- Explore options for better nutrition and exercise
I'd like to receive access to Harvard Health Online for only $4.99 a month.
Sign Me UpAlready a member? Login ».
Disclaimer:
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
You might also be interested in…

Understanding Depression
Depression is more than a passing bout of sadness or dejection, or feeling down in the dumps. It can leave you feeling continuously burdened and can sap the joy out of once-pleasurable activities. In Understanding Depression, find out how effective treatment can lighten your mood, strengthen your connections with loved ones, allow you to find satisfaction in interests and hobbies, and make you feel more like yourself again.
Free Healthbeat Signup
Get the latest in health news delivered to your inbox!