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Omega-3 fatty acids for mood disorders

October 27, 2020

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Comments

Sylvia Olson
August 16, 2018

While I think the article is good, it does not tell the reader that most of fish oil capsules sold over the counter are unregulated, and contain widely different ingredients and potency levels. They are mostly a waste of money. If you have health concerns, you need to consult an MD or a Registered Dietitian. Not a naturopath, homeopath, or other pseudoscience practitioner. Eat a diet rich in whole grains, nuts, and some oily fish. I take a multivitamin supplement made by CVS, formulated for my gender and age. Not from the food supplement shelves, which are unregulated, and might contain anything at all, or nothing but vegetable oil or cornstarch.

David Mischoulon, MD, PhD
August 20, 2018

Your concerns are very valid. The quality of commercially available omega-3 preparations can vary greatly. In our clinical trials we use preparations made by reputable manufacturers with high standards. We also have the preparations analyzed by 2 independent labs to confirm omega-3 content, impurities, and degree of oxidation, prior to initiating the study. While omega-3 fatty acids–like most nutrients–are ideally obtained through dietary practice, because many people may not enjoy omega-3 containing foods, supplements may be a good option for these individuals. Anyone who is interested in using an omega-3 preparation for treating a psychiatric condition should do so preferably under the supervision of a psychiatrist.

Nand Dhawan
August 14, 2018

Vegetable sources of omega 3 fatty acids are flax seeds,chia seeds and certain oils like soya oil & canola oil for vegetarians.flax seeds are also very useful for intestine.

David Mischoulon, MD, PhD
August 20, 2018

The omega-3s found in vegetable sources differ from those found in fish. There is less evidence for psychiatric effects from omega-3s (e.e. alpha linolenic acid) coming from vegetable sources, though they have general health benefits.

Mohamed haariz
August 14, 2018

How can I participate in a omega 3 study

David Mischoulon, MD, PhD
August 20, 2018

You can check the website clinicaltrials.gov, which lists different kinds of clinical trials and whether they are recruiting new subjects. Perhaps there is a study in your area for which you may qualify.

Dan L. Campbell, Research Biologist
August 14, 2018

Since there seems to be relatively minor advancement in treating the severe moods of Alz, what would be the negative effects of Omega-3 and Omega-6 fatty acids to help treat this problem?
While I do not pretend to know any answers to this problem, I experience/see the problems every day, and try to find what can be done.

Dr Edmond O`Flaherty , physician in Dublin
August 13, 2018

My initial interest in omga-3 was an article by Dr Andrew Stoll in Harvard about May 99, One of my bipolar patients had extreme OCD related to HIV which was not relevant to her. I put her on 9.6g of fish oil and continued her on her regular medication. She was well for the next 3 years with no obvious mental health problem when she was attending here.

Gar
August 13, 2018

Why don’t you just tell people to eat foods that have Omega 3’s instead of trying to push supplements?

I eat a very healthy diet and doing very well without taking pills.

David Mischoulon, MD, PhD
August 20, 2018

Good for you for eating healthily! Sadly, many people do not like omega-3 containing foods such as fish, and for these people, supplementation may be a good alternative to obtain omega-3. As a clinical investigator, my research focuses on study supplements, which is what I was asked to cover in this article. I’m all for healthy eating, but not everyone can afford it or wants to eat certain foods, and this is perhaps why supplements are so popular.

KATHRYN IRADI
August 13, 2018

How would one sign up for a Omega 3, study?

David Mischoulon, MD, PhD
August 20, 2018

You can check the website clinicaltrials.gov, which lists different kinds of clinical trials and whether they are recruiting new subjects. Perhaps there is a study in your area for which you may qualify.

Jeremy W Potash
August 13, 2018

Have you also investigated the efficacy of purslane as a souce of Omega 3. Purslane (Portulaca olearacea) is a big part of the mountain vegetable diet of the Tujia minority in western Hunan (delicious), for example, and is consumed globally. Was glad to find it in local farmer’s market in California, and even happier to learn about its health benefits including Omega 3. The fish oil capsules are so huge… much better to sprinkle purslane or stir fry it…

David Mischoulon, MD, PhD
August 20, 2018

I have not studied this source of omega-3. Thank you for pointing it out!

Jim Fiaschetti
August 4, 2018

If there was any doubt, here is the science.

https://news.illinois.edu/blog/view/6367/532158
CHAMPAIGN, Ill. — Chemical compounds called cannabinoids are found in marijuana and also are produced naturally in the body from omega-3 fatty acids. A well-known cannabinoid in marijuana, tetrahydrocannabinol, is responsible for some of its euphoric effects, but it also has anti-inflammatory benefits. A new study in animal tissue reveals the cascade of chemical reactions that convert omega-3 fatty acids into cannabinoids that have anti-inflammatory benefits – but without the psychotropic high.

The findings are published in the Proceedings of the National Academy of Sciences.

Foods such as meat, eggs, fish and nuts contain omega-3 and omega-6 fatty acids, which the body converts into endocannabinoids – cannabinoids that the body produces naturally, said Aditi Das, a University of Illinois professor of comparative biosciences and biochemistry, who led the study. Cannabinoids in marijuana and endocannabinoids produced in the body can support the body’s immune system and therefore are attractive targets for the development of anti-inflammatory therapeutics, she said.

Jim Fiaschetti
August 4, 2018

Since omega threes can be converted to cannabinoids in the gut, therein may lie some of the mechanisms that could help you explain the effects. The endocannabinoid system may end up being our primary endocrine system truth be known.

Carl Kennedy
August 3, 2018

Great work and article! Although ssri treatment provided immediate help for chronic mda, the help came side effects. After several months I was able to exchange viibryd for supplements. Looking forward to more news!

David Mischoulon, MD, PhD
August 20, 2018

Thanks very much! I’m glad you were able to come off the SSRI and maintain your benefit with supplements. Not everyone is so lucky!

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