Staying Healthy

Low-dose aspirin now the preferred agent to help prevent blood clots after knee replacement

In the journals

  • Reviewed by Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing
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A 2024 observational study highlights why orthopedists more often prescribe low-dose aspirin rather than an anticoagulant drug for preventing blood clots after a total knee replacement. Blood clots can be a serious complication of orthopedic surgery. Without preventive treatment, clots can form in a leg, break away, and travel to the lungs, causing a potentially fatal blockage called pulmonary embolism (PE).

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About the Author

photo of Matthew Solan

Matthew Solan, Executive Editor, Harvard Men's Health Watch

Matthew Solan is the executive editor of Harvard Men’s Health Watch. He previously served as executive editor for UCLA Health’s Healthy Years and as a contributor to Duke Medicine’s Health News and Weill Cornell Medical College’s … See Full Bio
View all posts by Matthew Solan

About the Reviewer

photo of Howard E. LeWine, MD

Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

Dr. Howard LeWine is a practicing internist at Brigham and Women’s Hospital in Boston, Chief Medical Editor at Harvard Health Publishing, and editor in chief of Harvard Men’s Health Watch. See Full Bio
View all posts by Howard E. LeWine, MD

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You might also be interested in…

Total Knee Replacement

If you need a replacement, or think it’s time to seriously consider it, Harvard’s Total Knee Replacement guide is invaluable. This guide can help you make that important decision, in consultation with your primary care doctor and orthopedic specialist. You’ll find a list of critical questions to ask your doctor to help ensure you have the best possible surgeon. The guide explains why people end up needing knee replacement, the alternatives to surgery, the different types of knee implants, the risks and complications of surgery, and how to make a safe and full recovery.

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