Staying Healthy

Low-dose aspirin now the preferred agent to help prevent blood clots after knee replacement

In the journals

By , Executive Editor, Harvard Men's Health Watch
  • Reviewed by Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

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A 2024 observational study highlights why orthopedists more often prescribe low-dose aspirin rather than an anticoagulant drug for preventing blood clots after a total knee replacement. Blood clots can be a serious complication of orthopedic surgery. Without preventive treatment, clots can form in a leg, break away, and travel to the lungs, causing a potentially fatal blockage called pulmonary embolism (PE).

In this study, researchers included 94,000 people who had total knee replacement over a 10-year period and received either low-dose aspirin, an anticoagulant (warfarin, a direct oral anticoagulant, or low-molecular-weight heparin), or both types of medication. They found among people who took only low-dose aspirin, there were significantly fewer cases of blood clots and PE within 90 days after surgery and less chance of a bleeding complication (a risk of both methods of blood clot prevention), compared with patients who took anticoagulants. The study was published July 17, 2024, in The Journal of Bone and Joint Surgery.

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About the Author

photo of Matthew Solan

Matthew Solan, Executive Editor, Harvard Men's Health Watch

Matthew Solan is the executive editor of Harvard Men’s Health Watch. He previously served as executive editor for UCLA Health’s Healthy Years and as a contributor to Duke Medicine’s Health News and Weill Cornell Medical College’s … See Full Bio
View all posts by Matthew Solan

About the Reviewer

photo of Howard E. LeWine, MD

Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing

Dr. Howard LeWine is a practicing internist at Brigham and Women’s Hospital in Boston, Chief Medical Editor at Harvard Health Publishing, and editor in chief of Harvard Men’s Health Watch. See Full Bio
View all posts by Howard E. LeWine, MD

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