Recent Blog Articles

Heart Beat: Controversial warning on Plavix and stomach-protecting medications

Updated: February 01, 2010

In November 2009, the FDA sent a letter to doctors warning that omeprazole (Prilosec, Zegerid, generic) can halve the clot-blocking action of clopidogrel (Plavix). The letter recommended that omeprazole not be taken with Plavix. The alert is something of a turnabout, since omeprazole was once recommended as an antidote to the stomach upset Plavix can cause.

The warning seemed premature, since it didn't include results of the Clopidogrel and the Optimization of Gastrointestinal Events (COGENT) trial, which were presented at a cardiology meeting in September 2009. Among more than 3,600 men and women taking Plavix, rates of heart attack or other cardiovascular events were identical in those taking the drug plus omeprazole and in those taking Plavix alone, but there were fewer gastrointestinal problems in the combination group.

To continue reading this article, you must log in.

Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School.

  • Research health conditions
  • Check your symptoms
  • Prepare for a doctor's visit or test
  • Find the best treatments and procedures for you
  • Explore options for better nutrition and exercise
Learn more about the many benefits and features of joining Harvard Health Online »

I'd like to receive access to Harvard Health Online for only $4.99 a month.

Sign Me Up

Already a member? Login ».

Disclaimer:

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.