Recent Blog Articles

Heart Health

Restless legs linked to broken hearts

September 26, 2012

About the Author

photo of Daniel Pendick

Daniel Pendick, Former Executive Editor, Harvard Men's Health Watch

Daniel Pendick is a former executive editor of Harvard Men’s Health Watch. He previously served as editor and chief writer for the Cleveland Clinic Men’s Health Advisor and Mt. Sinai School of Medicine’s Focus On Healthy … See Full Bio
View all posts by Daniel Pendick


As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.

No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.


Paul F Davis
October 31, 2012

Thank you for this post and discussion on matters of the heart, emotions and overcoming personal pain. As someone who went through a personal ground zero when my ex-wife of 5 years had an affair, I can feel and heal you. I wrote ‘Breakthrough For A Broken Heart’ when processing my personal pain and resurrecting my heart to live again. Truly we can transcend our trials and tribulations to love again and live our dreams!

Clinica de Sueño Alicante
October 17, 2012

The data obtained in this study, based on the potential relationship between RLS and the subsequent development of pathological cardiovascular, may constitute the starting point for using the presence or not of RLS as screening or early marker of coronary artery disease and also act as factor prevention in women who suffer, to conduct regular checks cardiology.

Cecilia Wallace
October 10, 2012

I found that 1000 mcg of vitamin B12 just before bedtime has stopped my restless leg syndrome. I questioned my physician about this and he said he had heard of the treatment but I’m the first that said it does work.

October 9, 2012

I am grateful to you for your lovely post it is full of information it really help to make a healthy life.

Abbey Newell
October 4, 2012

Being knowledgeable in body fitness is greatly good to us especially in our health

October 3, 2012

Good post for ever one that who suffering from this restless activity, the tips are most useful. thanks for sharing.

Jery Jhons
October 3, 2012

very useful information delivery thanks for post

Barbara S.
October 2, 2012

Have your Iron level tested! This is not the same as a general blood test. I was found to be low in iron and my long-term RLS disappeared within 48 hours of starting an iron supplement.

Steve Hunt
October 1, 2012

I have legs that jerk every minute or two around 9:00-10:00 PM onset. I’m told it is in the same family as RLS. I take Mirapex or Pramipexole .50 MG after dinner and it usually helps. In the article Dr. Winkleman indicated there were 4 drugs that were FDA approved that are remarkably effective to improve sleep. If he could respond, I would like to know what these drugs are. Thank you for a great article.

P.J. Skerrett
October 2, 2012

Steve — The four FDA-approved drugs are:

gabapentin (Horizant) [just approved a few weeks ago]
pramipexole (Mirapex)
ropinirole (Requip)
rotigotine (Neupro)

Jay Heggins
October 1, 2012

Great article. This presents some interesting new insights to the world of RLS…

October 2, 2012

I have suffered w/RLS for over 20 yrs now, I only found a remedy being Mirepex, 12 yrs ago. I tried colanzapam but it never did anythng for RLS, I thought it was for anxiety.
Anyway, Mirepex really was a life changer for me, both GOOD & Bad!
I found my personality changed, I became excessive in everything I did and do. I find I have more control over my addictions, but still not 100%
Did anyone on Mirepex notice any unusual character changes?

Dave Cramer
September 30, 2012

I believe RLS is a factor in many other medical disorders and one should not get the impression it is only an isolated symptom of cardiovascular health issues.

Jay Rosen
September 30, 2012

I did not see the original article. Causation is theorized but not tested for. IE: no study to see if treatment of RLS
prevents CAD. How about comparing stats on a long-term treated population vs untreated?

David Wimble
September 30, 2012

Inflammation is believed to be a key factor when it comes to Restless Legs Syndrome. A new study was published in the January 14, 2012 issue of “Sleep Medicine Review Journal” that supports this theory. You can read that study here:

You can view the results of other related scientific studies and learn about some helpful solutions at this free RLS information website:

A blog for RLS sufferers with helpful tips can be found here:

October 2, 2012

thank you, that is the first time anyone gave me any real info that was not medication

It will be hard cause I am not good at following stuff like this, but if it means no RLS w/o meds, hey, it works for me.
thank you will def try this
I can see why you did this, if I had knowledge that helps, knowing how much this RLS has effected my LIFE. I would of done it too

riki josh
September 29, 2012

I usually have the urge to move my legs mot time when sitting, thanks for this enlighthen article. Nice research work..

September 28, 2012

Thank you Daniel Pendick, for such a splendid and helpful article.

Kris Mazalewski
September 28, 2012

These articles are invaluable. Thank you for your tremendous efforts and research!

Cyril Baldachin
September 27, 2012

I take 300 mgms of magnesium every evening and this keeps my RLS in check. Occasionally, about once every two weeks, I take a 300 mgm iron tablet. If I don’t do this RLS is practically unbearable. Last I checked with my doctor, he didn’t seem to think anything was wrong withy this.

October 2, 2012

I do not know how this works, since Magneseum is almost impossible to retain.

The IRON makes sense, I know I am very low in Vit B12
am in the process of boosting it up?

Thnks for sharing

Nancy Whedon
September 27, 2012

Well for those who think RLS is bogus, I sure wish you could experience it JUST once! It will not allow you to sleep. You must get up and move around,or get into a movie or activity to take your mind off of it. BEFORE the activity I have to take Ibuprofen to take away the feeling of RLS. Usually half an hour does it and hopefully then I can try to go back to sleep.I have tried to correlate it to the days activities, either super busy and perhaps stressful physically versus a slower paced day. It doesn’t always happen when busy, and sometimes happens when slower paced. I just hope that others with this have people around them that believe them, or it can make you feel like a hypochondriac,(which you aren’t!!)

James Patterson
September 27, 2012

I really appreciate this post. I have been looking all over for this! I found this site on Google. It was excellent and very informative.

Commenting has been closed for this post.

Free Healthbeat Signup

Get the latest in health news delivered to your inbox!

Harvard Health Publishing Logo

Thanks for visiting. Don't miss your FREE gift.

The Best Diets for Cognitive Fitness, is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School

Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health, plus the latest advances in preventative medicine, diet and exercise, pain relief, blood pressure and cholesterol management, and more.

Harvard Health Publishing Logo

Health Alerts from Harvard Medical School

Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight loss...from exercises to build a stronger core to advice on treating cataracts. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts.

BONUS! Sign up now and
get a FREE copy of the
Best Diets for Cognitive Fitness

Harvard Health Publishing Logo

Stay on top of latest health news from Harvard Medical School.

Plus, get a FREE copy of the Best Diets for Cognitive Fitness.