New warning on coronavirus symptoms in children — what parents need to know

Claire McCarthy, MD

Senior Faculty Editor, Harvard Health Publishing

While most children who get COVID-19 have a mild or even asymptomatic illness, there are new reports that some children may have a complication that can be severe and dangerous.

Called multisystem inflammatory syndrome in children (MIS-C) by the Centers for Disease Control and Prevention, it can lead to life-threatening problems with the heart and other organs in the body. Early reports compared it to Kawasaki disease, an inflammatory illness that can lead to heart problems. But while some cases look very much like Kawasaki’s, others have been different. Experts think that MIS-C is likely a reaction of the body to either a current or past COVID-19 infection — but there is much we don’t understand, including why some children with MIS-C have negative tests for COVID-19.

What are the symptoms of the new inflammatory syndrome known as MIS-C?

Symptoms of MIS-C vary from case to case, but can include

  • prolonged fever (more than a couple of days)
  • rash
  • conjunctivitis (redness of the white part of the eye)
  • stomachache
  • vomiting and/or diarrhea
  • a large, swollen lymph node in the neck
  • red, cracked lips
  • a tongue that is redder than usual and looks like a strawberry
  • swollen hands and/or feet
  • irritability and/or unusual sleepiness or weakness.

There are many other conditions that can cause these symptoms. For example, strep throat can cause fever, rash, swollen lymph nodes, and a “strawberry tongue,” and there are plenty of common viruses that cause stomachache, vomiting, and diarrhea. Doctors make the diagnosis of MIS-C based not just on these symptoms, but also on their physical examination as well as medical tests that check for inflammation and how organs are functioning.

What parents need to know about MIS-C

We are just learning about MIS-C. At this point we have many more questions than answers. But here is what parents need to know about this syndrome:

  • It is rare. While there is a lot about it in the news, the number of cases is actually low, especially when you consider how widespread COVID-19 has become. Parents should not panic if their child gets one of these symptoms, or if they are diagnosed with COVID-19.
  • It is treatable. Doctors have had success using various treatments for inflammation, as well as treatments to support organ systems that are having trouble. While there have been some deaths, most children who have developed this syndrome have recovered.
  • It is serious. That’s why it’s important to be vigilant. Call the doctor if your child develops symptoms on the list above, particularly if they have a prolonged fever (more than a couple of days). While it’s especially important to call if your child has been diagnosed with COVID-19 and develops one or more of these symptoms, you should call even if they haven’t. If your doctor isn’t concerned, that’s great — but if the symptoms get any worse or just don’t improve, call again or bring your child to an emergency room.

Many parents are afraid to take their children out of the house during the COVID-19 pandemic, let alone to a doctor’s office or hospital. That’s understandable, but it’s important not to let that fear endanger your child’s health. If you are worried about your child — for this or any reason — call your doctor. Together you can figure out how to get your child the care they need.

Follow me on Twitter @drClaire

For more information on coronavirus and COVID-19, see the Harvard Health Publishing Coronavirus Resource Center.

Related Information: Harvard Health Letter


  1. Marla Andreoli-Weber

    As a teacher who’s students live in low income, tenement buildings, I’m very concerned about their status. Additionally, being 61 years old with two autoimmune disorders, makes me wonder what situation I will be placed in by the government, as they try to reopen the nation. Additionally, I work in a rural, high poverty State, and our risk factors have yet to be determined. Couple that with families in rural areas that don’t have health insurance, as they do not seek medical assistance if/when symptoms show.

  2. Andrew

    Can a child with MIS-C and at the same time have COVD-19

  3. Layne

    An outstanding share! I have just forwarded this onto a colleague who has been conducting
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    • Georgie

      My little boy who is 2 1/2 had all these symptoms the week before we went into lockdown. We ended up taking him to a walk in centre where they said he had scarlet fever, gave us a course of antibiotics and told use to inform public health. He was really ill with a fever, swollen gland, sore throat, bright pink blotches all over is body, vomiting and diarrhoea, craked lips and irritable. I read something a few weeks ago about this happening to children in NY but doctors didn’t know what was causing it. It got me thinking that it could be connected to covid, so ive been looking into it since. Any more info on this would be much appreciated

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