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Anti-inflammatory medications and the risk for cardiovascular disease: A new study, a new perspective
- By Robert H. Shmerling, MD, Senior Faculty Editor, Harvard Health Publishing
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
I use Curcumin disolved in olive oil. Perhaps not very medical approved but it did wonders for me.
I think study honesty and limitations is a good point to clarify upfront as the future for all credible health websites will be disclosure. The problem with any study’s conclusion is limitations and cost. The more we spend the more we will know but that is a luxury we don’t seem to have and so people must use common sense and wisdom to make their own decisions taking into account their particular circumstance and ability to become informed. I think it would be more helpful to line up people’s life styles and health experience against a selection of possible remedies so that people can see that they have choices. For example I read an advert at a Pharmacy that said that there is no cure for diabetes. They were trying to bring attention to monitoring devices. In truth there is no pharmaceutical cure but there is a diet cure for type 2. The advert was half truthful only and this is not helpful in the long run. There clearly is a necessity for monitoring devices for a particular lifestyle person in mind but not for all. Advice should be given with different types of people in mind.
The post is very nice to visible and excellent to provide the wonderful tips to the public.
This article does not specify the number of participants, gender balance, age balance, genetic/racial balance, or the duration of the study. Nor does it discuss the funding sources or the entity collecting and analyzing the data. What was the dropout rate of originally enrolled, for instance? These are all issues (and there may be more) which need to be considered when deciding the applicability to any individual. By the way, what medication was used to protect the stomach?
Excellent, necessary points were raised by you. Variables were either negligently or deliberately omitted.
I have a personal grudge against Celebrex, only based on one person’s experience, and therefore having no scientific validity. But, what he went through with sudden painful swelling of his legs, right after beginning a Celebrex prescription! Wouldn’t want anyone else to go through this. I would caution others to seek an alternative to jeopardizing their leg veins’ ability to function properly. We immediately informed his doctor, but were told there was no connection between the sudden onset of his symptoms, and the date of beginning the Celebrex. He believed his doctor. His doctor believed the pharmaceutical company. The patient continued taking the Celebrex and the swelling and pain in his legs increased. Even after he stopped taking the Celebrex ,and changed doctors, the swelling in his legs continued for years. He had to have help to put on compression stockings every morning. He eventually developed fluid retention in his lungs, congestive heart failure. This is only anecdotal evidence, but it’s still true.
Iyengar yoga done with expert instruction consistently has helped my n osteoarthritis in Basel thumb joints and knees. Years and years ago I was told my thumb joints were bone upon bone. I took viox for awhile…After a million down dog asanas my hands are fine most of the time…for arthritic kneecaps sitting in virasana and doing yoga style squats help a lot. Movement is the secret but it has to be the right kind of movement done with appropriate props.
Acupunture works really good to reduce inflammation/ pain. According to my practice of 10 years Acupuncture and chinese Medicine is very very effective holistically treating the patient from root cause with no or fever side effects. After successful Acupuncture treatments , most of patient actually do not need any inflammatory drugs. As mentioned in above comment that taking R Alpha lipioc acid, turmeric, ginger ,garlic etc are good alternatives. Even supplements like Vit D3, magnesium and omega3 are good health.
In Harvard Health’s words, “…this was a large, well-designed, and expensive study that is unlikely to be repeated any time soon.”
It’s good that you point out some of the deficiencies of the study; it’s bad, very bad, that you give the manufacturer a pass when from the first word of your account it was evident even to this layperson that the study was indeed well-designed — to carefully sidestep any possible bad news. The manufacturer clearly knew what to avoid in the study, as if they had previously done multiple small-scale studies to learn what to exclude.
Shame on Harvard Health!
My biggest concern is a comparison between aspirin and celecoxib.
I do have the risk factors of high cholesterol and big family history
of CV problems. I take aspirin for arthritis pain and always have,
without any side effects. The question for me has always been whether
celecoxcib or aspirin works better-but no one has ever tested those
two against each other. Has that ever happened and I missed it?
I take Protonix 40 mg bid, so I’m ok there. Can someone discuss
this, please? Thank you.
I am wondering how much better a study using a control would be. On a scale of 1to 10, how would a research trial team rate the controlled trial over the non-control trial?? I would guess that a non-control trial would border on NOT being scientific.
If you want to control inflammation, which you should, then why not use R-alpha lipoic acid as prescribed by the German health establishment? I have just cured my own case of intercostal neuralgia plus Amla fruit extract in two weeks after suffering for over 3 months. Turmeric and black pepper is also a great anti-inflammatory.
Was Meloxican tested? Is it considered an “anti-inflammatory ” drug? I was prescribed it for ostio-arthritus.
I would like to see Cox-2 inhibitor safety and efficacy compared with dietary/physical changes or anti-inflammatory supplements like curcumin. Of course, these studies will likely not be performed because the profits, compared with drugs like Celebrex, are not adequate. We are in a healthcare system that is too profit-driven.
Benefits outweigh the risk.Now i think it is time to rule out exactly there is more benefit will get the patient by using a drug or not.Here Cox-1 or Cox-2 are using to relieve arthritis pain.With out using Cox-1 or Cox-2 the patient can extent his life .Better to keep this medicines under investigation until getting clear picture.
I have moderate ostio arthritis of hips and lower spine. I now take low dose ibuprofen (400mg) per day. It relieves the pain everytime I move my hips and greatly improves my quality of life.
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