Harvard Health Letter

What you should know about: PPIs

Proton-pump inhibitors (PPIs) are drugs that are often prescribed for people who suffer from chronic heartburn or another digestive disorder. They are available over the counter and by prescription. They work by reducing the production of stomach acid. PPIs are generally safe when used in the short term; however, they do carry some risks in the long term, such as hip fracture, pneumonia, and a type of life-threatening gastrointestinal infection. PPIs may also interfere with clopidogrel (Plavix), a blood thinner.
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