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Grapefruit, drug interactions
The potency of some cardiovascular and other drugs is affected by grapefruit, pomelo, and other juices. Some of the most common drugs affected by grapefruit are listed below.
Drugs that interact with grapefruit
Grapefruit and grapefruit juice can boost blood levels of various prescription medications. Keep in mind that each category contains several other medications that aren't affected by grapefruit.
Drug category (major uses)
Statins (lowering cholesterol)
atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, generic)
Calcium-channel blockers (high blood pressure, angina)
diltiazem (Cardizem, others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nisoldipine (Sular), verapamil (Covera, Verelan)
Other cardiovascular drugs
amiodarone (Cordarone, Pacerone), cilostazol (Pletal, generics), losartan (Cozaar, Hyzaar)
Immunosuppressants (prevent organ rejection)
cyclosporine (Gengraf, Neoral, others), tacrolimus (Prograf, Protopic)
Sedatives (anxiety, insomnia)
diazepam (Valium, Diastat, Dizac), midazolam (Versed), triazolam (Halcion)
Other neurological and psychiatric medications
buspirone (BuSpar), carbamazepine (Tegretol, Epitol, Carbatrol), sertraline (Zoloft)
Phosphodiesterase inhibitors (erectile dysfunction)
sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra)
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