Recent Blog Articles

Heart Health

What you should know about: Statins

October 01, 2012

Statins are among the most widely prescribed drugs in the world, because they are effective at lowering low-density lipoprotein (LDL, or unhealthy) cholesterol levels. Elevated LDL levels are a major risk factor for heart disease, heart attack, and stroke. But there are many opinions about who should take statins. Some cardiologists believe statins should be prescribed to people with mild heart disease risks. Others feel statins should be reserved only for those with moderate or severe heart risks.


Two recent studies add to the debate. One, published in The Lancet, suggested that the guidelines for statin therapy be revised to include even people at low risk for a vascular event. The other, from Harvard-affiliated Brigham and Women's Hospital (BWH), published in The Lancet, counters recent concerns that statins can be associated with an increased risk of type 2 diabetes. The BWH study found that the cardiovascular and mortality benefits of statin therapy exceed the diabetes hazard, even among those with the highest risk of developing diabetes. "The risk of developing diabetes while on statin therapy was limited almost entirely to people who had at least one major risk factor for diabetes prior to statin therapy," says Dr. Paul Ridker, the study's lead author and the director of the Center for Cardiovascular Disease Prevention at BWH. "Yet even in this high-risk group, the benefits of treatment greatly outweighed the diabetes hazard."

To continue reading this article, you must log in.

Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School.

  • Research health conditions
  • Check your symptoms
  • Prepare for a doctor's visit or test
  • Find the best treatments and procedures for you
  • Explore options for better nutrition and exercise
Learn more about the many benefits and features of joining Harvard Health Online »

I'd like to receive access to Harvard Health Online for only $4.99 a month.

Sign Me Up

Already a member? Login ».


As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.