Recent Blog Articles

Heart Health

On the horizon: Removing fat makes HDL ("good cholesterol") even better

January 01, 2011

High-density lipoproteins (HDL) protect the heart and arteries by removing cholesterol lodged in artery walls and riding through the bloodstream inside of low-density lipoproteins (LDL). Here's a novel way to amplify HDL's cholesterol-busting activity: Take some blood from a person. Extract the HDL. Use a process called delipidation to remove cholesterol and other fats (lipids) from the HDL. Then put the defatted HDL particles back into the bloodstream. This seems to turbocharge HDL and make it work even more aggressively against cholesterol.

illustration of high-density lipoprotein particle

In the first clinical trial of HDL delipidation in humans, the procedure was safe and effective. Treated HDL caused cholesterol-filled plaque to shrink more than did untreated HDL (Journal of the American College of Cardiology, June 15, 2010). The trial was too small and didn't last nearly long enough to see if this prevented future heart attacks or improved survival.

To continue reading this article, you must log in.

Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School.

  • Research health conditions
  • Check your symptoms
  • Prepare for a doctor's visit or test
  • Find the best treatments and procedures for you
  • Explore options for better nutrition and exercise
Learn more about the many benefits and features of joining Harvard Health Online »

I'd like to receive access to Harvard Health Online for only $4.99 a month.

Sign Me Up

Already a member? Login ».


As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.