Harvard researchers identify genetic cause for a form of cardiomyopathy

Published: June, 2012

Dilated cardiomyopathy is a disease of the heart muscle that affects its ability to pump. In people with this condition, the chambers of the heart become enlarged, and the walls become thin. Over time, the heart's ability to pump gradually weakens. Eventually, the heart becomes so weak that it is unable to pump a sufficient amount of blood to the body and lungs. This is heart failure.

Dilated cardiomyopathy can be caused by a variety of medical conditions and lifestyle choices, as well as genetic mutations. Recently, Dr. Jonathan Seidman and Dr. Christine Seidman, both professors of genetics at Harvard Medical School, discovered that a mutation on the TNN gene causes about 27% of inherited dilated cardiomyopathy cases and about 20% of cases that occur sporadically. Their research was published in the New England Journal of Medicine on February 16, 2012.

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