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Heart Health

Some antibiotic, antifungal drugs don’t mix with warfarin

June 7, 2012
  • By Holly Strawbridge, Former Editor, Harvard Health

About the Author

photo of Holly Strawbridge

Holly Strawbridge, Former Editor, Harvard Health

Holly Strawbridge was the executive editor of the Harvard Heart Letter from May 2012 to June 2013. See Full Bio
View all posts by Holly Strawbridge


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lexy layne
August 3, 2012

stopped taking coumadin after hellp syndrome, pulmonary embolism and stroke i stopped on my own but experiencing bruising and high blood pressure

Mark A
July 28, 2012

I have been using warfarin for over 6 years now and have found that at least with my body if I do not make any drastic changes in food or drug intake it is possible to take certain herb and supplements which is some cases have let me lower my dosage of warfarin and still maintain my correct levels. You must keep up a strict sampling of your blood but with care you can even try things outside the normal once in awhile which is kind of fun.

June 21, 2012

Very interesting article. My grandfather has factor V liden and what the doctors are calling a “history” of A-Fib, which from what I have seen in his medical history was only a one time occurrence. He recently had surgery and the doctors put him back on his coumadin right away and now he’s on Cipro for a UTI. 3 weeks since his surgery, he experienced bleeding from the site – wondering how Cipro and Coumadin react, and if Coumadin is really necessary in his case, since he’s only had one documented incidence of A-Fib in 2006 and the coumadin is not being used for the Factor V. I would really like him off of it due to the possibility of bleeding out. Aren’t there any alternative meds that can replace Coumadin? Thanks, Erica

Justine RN at SNF
July 10, 2012

Never just stop taking coumadin. Once starting counadin a person should be tapered up or down in milligrams by frequent reviewing of the INR results when on antibiotics. If there is frequent varuiation in the results maybe get the INR test a couple of times a week to adjust the coumadin dose. If coumadin is stopped suddenly for a couple of days, seek medical assistance to prevent a pulmonary embolism, DVT or stroke. This is very important.

June 8, 2012

I was just reading this post, I was trying to find out about antibitics I have had several doses over the last couple of years, about 20 in all. I have developed a very idal bowel, and now they are saying it is as a result of antibiotics, although not exactly related to your post I thought I would comment, there is a lot that is not told.


Shannon van der Bilt
June 8, 2012

Thank you very much for this interesting article. Hope that it will warn many Warfarin-users.

Shannon van der Bilt

Marielaina Perrone DDS
June 8, 2012

Great research. Going to print this out and keep in my office for some of patients.

Marielain Perrone DDS

Commenting has been closed for this post.

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