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Probiotics for bipolar disorder mania

June 25, 2018

About the Author

photo of Marcelo Campos, MD

Marcelo Campos, MD, Contributor

Dr. Marcelo Campos works as a primary care doctor at Atrius Health. He is a lecturer at Harvard Medical School and a clinical assistant professor at Tufts University School of Medicine. Dr. Campos completed medical school … See Full Bio
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July 22, 2018

“We still do not know if an intestinal microbiome disarray is the cause of mania and bipolar disorder.” But we do know the antidepressants and ADHD drugs can create the symptoms of bipolar, including mania. And this iatrogenic pathway to a bipolar diagnosis has resulted in millions of people, including over a million children, being misdiagnosed as “bipolar.”

From the DSM-IV-TR: “Note: Manic-like episodes that are clearly caused by somatic antidepressant treatment (e.g., medication, electroconvulsive therapy, light therapy) should not count toward a diagnosis of Bipolar I Disorder.”

And we do know combining the antipsychotics and the antidepressants, which is part of today’s recommended bipolar treatments, can create psychosis and hallucinations, via the central symptoms of anticholinergic intoxication syndrome, aka anticholinergic toxidrome.

And we also know that weaning people off of the “bipolar” drug cocktails can result in a drug withdrawal induced “super sensitivity manic psychosis,” too.

Perhaps a good way to prevent most of the “bipolar,” would be to stop passing out the psychiatric drugs, that create the “bipolar” symptoms, like candy?

Do the Harvard doctors know that the head of the National Institute of Mental Health declared “bipolar,” and all the DSM disorders, to be “invalid” disease entities in 2013?

Martha Bullock
July 19, 2018

I have no doubt that the brain and the gut are connected – as manifested in many ways. Generally speaking, the brain/mind/body connection is well documented – work begun, I believe, by Candice Pert. However, I do wonder if there’s a way to know ‘which came first, the chicken or the egg’ – e.g. do these significant mood disorders come from changes in the brain, or inflammation in the gut? And, then too, does it matter, if they are so intimately connected? Since probiotics are good for many things, I’m not quite sure how their benefit for mood disorders is teased out from many other possible impacts. I’m very interested in learning more about this.

July 17, 2018

Hi there Bob,
Thanks for sharing your insights; a few questions:
– when you mention ‘its the bacteria that assist..’ what bacteria do you refer to?
– and what deficiencies are we talking about? Could you please share practical/ hand on advices for those to book progress?
Thank you so much!
* and out of curiosity, whats your background/ sources?

Ben Gunn
July 16, 2018

What probiotics ? There are many.

Diane Sommers
July 16, 2018

Is it possible to receive the article on the benefits of Probiotics ?

George Georgopoulos
July 16, 2018

Just another way to sell yogurt….now they say coffee is good for you…All about $$…..😤

Feryal Hijazi
July 16, 2018

Thank you, I am using probiotics since long period , I notice it started not to work as it has been.
Hi which probiotic brands do you suggest better.

July 16, 2018


July 16, 2018

We need to maintain a Vitamin D3 level of 40-70 year round Optimize magnesium levels(if you kidneys are good. Probiotics with most meals. We have taken too many antibiotics over our lifetimes and need to replenish our beneficial gut flora. Pain levels and depression will improve. Many take meds that deplete vital nutrients Statins deplete CoQ10 levels and cholesterol and we need cholesterol to synthesize Vit D. Also research Fluoridated water and negative health effects.

July 16, 2018

Julie A. Fast
July 16, 2018

This is worrying reporting. Please note that the people who took the probiotics were on medications. It seems to me that the research points to probiotics helping people better absorb medications- this would not be a correlation with it actually helping mania. This is still a positive finding, but the outcome inferences don’t work overall.

I expect more from a Harvard study. Thank you, Julie Fast

David E. Gleason
July 16, 2018

Kudos! It’s been tough not to become cynical. I mean, it sometimes seems that medicine has “just discovered” a connection between diet and health. Now that the one-time saviors of technology and drugs are showing their limitations, maybe we can start to focus on what we eat instead. I recently abandoned all drugs for my digestive problems, and switched to a FODMAP diet, and within a week, problems have vanished. Don’t know if this solution is going to prove successful for treating bipolar, but I give it a thumb’s up for heading in the right direction. We need a lot more research, and a lot more researchers with *new ideas* for health. Hopefully this is a major step in the right direction.

Sherry Mulhollan
July 16, 2018

What is the best probiotic to buy?

July 1, 2018

Now probiotics is also for Bipolar Disorder Mania. Just wow! day by day probiotics keep on improving or new research about it appears. A very good thing because probiotics are cheap but gives so much nutrition or benefit to our body. Thank you for this informative one!

June 26, 2018

What is your factual basis for this statement? Research reference please. It is so easy to state sensible sounding theories but much more difficult to truely establish a valid cause and effect relationship.

June 26, 2018

and it is not only about this bacteria, there are mycobacterium vaccae too helping with mental disorders

Dirt is great 🙂 .

June 25, 2018

It’s not the bacteria, it’s the fact that the bacteria assist in nutrient absorption.

The underlying neurological problems are from mineral and vitamin deficiencies.

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