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Harvard Health Blog
Baloxavir (Xofluza): A new antiviral drug for the flu
- By Daniel Kuritzkes, MD, Contributor
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
My 18 year old daughter got the flu this week and WOW this was amazing. Unlike the tamaflu… she did not have vomiting and nausea. I am AMAZED at how well this worked and how quickly she started feeling better.
I had been ill with Influenza Type A for close to 48 hours when I was prescribed Xofluza. My temperature fell from 103.5. to normal in about 18 hours and my respiratory distress decreased considerably. I’ve remained fatigued, however, and have yet to recover my appetite 48 hours on. Also, I’ve had diarrhea since taking the medicine. I had read that diarrhea is a side effect of Xofluza. To be sure, the fever was worse than the current stomach distress, but I wonder how long it will take for my digestive system to recover.
In the past, my doctor prescribed Relenza and Tamiflu for different bouts with the flu. Both worked well but this year, the flu caused me to be bedridden for 40 hours. I was too weak to pick up a phone and was finally dragged by my wife to the same doctor as before. He gave me Xofluza and told me that it is a single pill dose and that it is shown to provide relief faster than the previous drugs without having to take multiple pills. At the time I had 102 degree temperature and could hardly walk unassisted with my body aching to the point where I couldn’t close my hand with any amount of force. I asked him if it was safe and he told me that though it was approved only a few months ago by the FDA, it was used in Japan for 2 years already and I trusted him. He told me he is prescribing to me what he would do for himself. The result is I felt relief within 4 hours and by the morning 8 hours later, I was still a little wobbly but I was able to work on my van for several hours and change batteries. I am writing this 24 hours after taking the Xofluza and I feel well enough to the point where I am the same as before I got sick (not including the sore rib, stomach, and muscles from the fierce coughing from the past 48 hours).
I just had the flue and took Xofluza. The next day I was 90% better, body temp down to 99.0 from 102 the day before. You are not cured in 24 hours, but your are close. I did have the flu vaccine, I haven’t missed one in 20 years. The only reason I knew Xofluza existed was that my daughter took it the week before 2 states away.
My doctor tried to talk me into Tamiflu, but I asked for Xofluza. It wound up costing me $88.00 with a coupon and insurance at
I had a flu for 48 hours and my doctor prescribed Tamiflu for 5 days. I showed her the new drug Xofluza approved by the FDA, but she still insist on the former. She said the medical community still not ready to embrace the new drug. Is this true?
Baloxavir marboxil is an antiviral medication used to treat the flu (influenza) if your symptoms started less than 48 hours ago. It helps make the symptoms (such as stuffy nose, cough, sore throat, fever/chills, aches, tiredness) less severe and may shorten the recovery time by 1 to 2 days. Baloxavir marboxil works by stopping the flu virus from growing. It will not treat other kinds of infection besides the flu virus. Baloxavir marboxil is not a substitute for the flu vaccine.
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