Who’s at risk for fatty liver disease, from the Harvard Health Letter

Up to 20% of American adults have some degree of fatty liver disease, a condition that used to occur almost exclusively in people who drink too much alcohol. The increase can be blamed on the twin epidemics of obesity and diabetes, reports the January 2011 issue of the Harvard Health Letter. One leading theory is that the condition starts when muscle, fat, and liver cells stop responding normally to insulin. This so-called insulin resistance is a hallmark of obesity and diabetes. Insulin resistance also increases the amount of fat molecules circulating in the blood. The accumulation of these molecules inside liver cells can lead to liver inflammation and damage. This is called nonalcoholic steatohepatitis (NASH). NASH is often a relatively stable condition with few if any symptoms. But it can also lead to serious damage to the liver and its function — a condition called cirrhosis.
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