When considering alternative treatments to avoid a knee replacement, not all therapies are proven effective at reducing knee pain. The best treatments are weight loss and physical therapy, which relieve pressure on the knee joint. Supplements such as glucosamine and chondroitin, and therapies such as acupuncture and viscosupplementation, can be effective in some people. There is not enough evidence to show that platelet-rich plasma therapy (PRP) and prolotherapy are effective. Prolotherapy and viscosupplementation carry a risk of infection.
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