Proton pump inhibitor (PPI) medications such as omeprazole and lansoprazole are the most effective treatment for treating heartburn. But long-term use of a PPI may increase the risk for certain infections and reduce the absorption of some nutrients. This will probably not cause illness in most people. Some people may be able to stop taking a PPI and switch to a different medication if there is a concern. In some people, the risk of stopping a PPIs might be greater than the relatively small and uncertain risks of continuing to take it.
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