Caution: Popular painkillers may interfere with antidepressants, from the Harvard Mental Health Letter
Researchers analyzed the results of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a large “real-world” examination of depression treatment. Only 45% of STAR*D participants who took an SSRI along with a pain medication achieved complete relief of depression symptoms, while 55% of people who were taking an SSRI alone (without a pain medication) did so.
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