Skip to main content

More on gout: Once kingly, now common

Print This Page

Gout has been called the disease of kings because European royalty appears to have been disproportionately afflicted by the disease. Monarchs and other luminaries were described as having arthritic attacks that are strongly suggestive of gout attacks. And paintings done at the time show deformities that look to be tophi, the nodules of uric acid crystals characteristic of untreated gout.

Several years ago, Spanish researchers confirmed that Holy Roman Emperor Charles V (also known as King Charles I of Spain) was a gout sufferer. They used a scanning electron microscope to examine a finger that had been preserved separately from the rest of his body. They saw needle-shaped crystals containing large amounts of sodium, which is a solid clue that the Charles V had gout. This wouldn’t have been news to the emperor: he wrote about having gout in correspondence to his sister.

To continue reading this article, you must log in.

Source matters. Subscribe to HarvardHealthOnline+ FREE for 30 days for unlimited access to the site – where all content is reviewed by an HMS physician or faculty expert.

With HHO+ you get these exclusive benefits:

  • Unlimited access to all Harvard Health Online content
  • 4 expertly curated newsletters delivered monthly
  • Customized website experience aligned to your health goals
  • In-depth health guides on topics like sleep, exercise, and more
  • Interactive features like videos and quizzes
  • Members-only access to exclusive articles and resources

SPECIAL OFFER! UNLOCK EXPERT ACCESS for 30 days FREE!

Already a member? Login ».

Print This Page

Disclaimer:

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.

No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

Free Healthbeat Signup

Get the latest in health news delivered to your inbox!

Sign Up