By the way, doctor: Is there any drawback to hyaluronic acid capsules?

Published: February, 2009

Q. I have been taking capsules containing hyaluronic acid for my knees. Is there any downside to this medication?

A. Hyaluronic acid, hyaluronate, and hyaluronan are different names for the same, viscous substance. Hyaluronic acid is one of the main ingredients of the synovial fluid that lubricates the joints. Part of the reason joints get arthritic is that the fluid starts to break down, so replenishing a bad knee with "fresh" hyaluronic acid makes some sense, and the FDA has approved injections of hyaluronic acid into the knee as a treatment for osteoarthritis. The injections are hardly a cure, but they're reasonably effective, providing about as much pain relief as taking an oral painkiller like ibuprofen or naproxen. Some injectable products (Hyalgan, Supartz, others) are made from "natural" hyaluronic acid derived from the combs of roosters; another (Synvisc) is made from a related synthetic substance called hylan G-F 20. It's not clear which is better.

To continue reading this article, you must log in.
  • Research health conditions
  • Check your symptoms
  • Prepare for a doctor's visit or test
  • Find the best treatments and procedures for you
  • Explore options for better nutrition and exercise

New subscriptions to Harvard Health Online are temporarily unavailable. Click the button below to learn about our other subscription offers.

Learn More »