Aspirin may prevent blood clots in the legs from recurring
People who develop blood clots in their legs—a condition called venous thromboembolism—must take warfarin (Coumadin) for several months or longer to prevent another clot from forming and possibly traveling to the lungs, with deadly results. Yet warfarin can cause unwanted bleeding and requires regular blood testing. As a result, no one wants to be on this treatment forever. The question is, what else might they do to reduce their risk for another blood clot if they stop taking warfarin?
Now the combined results of two compatible studies have determined that a low dose of aspirin (100 mg per day) may be an effective substitute for long-term use of warfarin. Both studies examined people who had developed a clot in the legs for unknown reasons. In both studies, the clots were dissolved with heparin, and treatment with warfarin followed for up to three months. Then warfarin was discontinued, and the study participants were given either daily low-dose aspirin or placebo (sugar pill). Compared with placebo, aspirin reduced the rate of recurrent clots by one-third, and helped prevent strokes, heart attacks, and other undesirable consequences, with a very low risk of bleeding. The researchers concluded that low-dose aspirin would be a reasonable option for long-term clot prevention in people who suffer a first clot for unknown reasons.
To continue reading this article, you must log in.
Subscribe to Harvard Health Online Plus (HHO+) to unlock expert-backed health insights, personalized tools, and exclusive resources to feel your best every day.
Here’s what you get with your HHO+ membership:
- Unlimited access to all Harvard Health Online content
- 4 expertly curated newsletters delivered monthly
- Customized website experience aligned to your health goals
- In-depth health guides on topics like sleep, exercise, and more
- Interactive features like videos and quizzes
- Members-only access to exclusive articles and resources
I’d like to subscribe to HHO+ for $4.99/month to access expert-backed content to help make smart, informed decisions about my well-being.
Sign Me UpAlready a member? Login ».
Disclaimer:
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.