By the way, doctor: What does Indolplex do?

Q A preventive doctor told me to take Indolplex (bioavailable diindolylmethane or DIM) to aid estrogen metabolism. Is there any research available about this supplement?

A Indolplex is an over-the-counter supplement containing an extract of diindolylmethane (DIM), a chemical found in cruciferous vegetables, such as broccoli, Brussels sprouts, cauliflower, and cabbage. Its manufacturers promote DIM as an "aid to estrogen metabolism" because it appears to reduce the ratio of potent estrogens in the body to weaker ones.

During normal metabolism, estrogen converts to many forms, called metabolites. Some estrogen metabolites have stronger estrogenic effects on bone, breast, and endometrial tissue than others. According to the Indolplex advertisements, decreasing the ratio of stronger to weaker estrogen metabolites promotes "optimal breast health"; the implication is that the supplement can reduce a woman's risk of developing estrogen-linked conditions, such as breast cancer and lupus.

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