By the way, doctor: Do I need CTX testing during a Fosamax "holiday"?
Q. I'm 69 and have been taking Fosamax for 10 years. My doctor has approved a "drug holiday," provided we use a CTX test to monitor my bones. Can you explain?
A. CTX — which stands for C-terminal cross-linked telopeptide — is an indicator of bone turnover. Turnover refers to the remodeling process by which bone is continually broken down (resorption) and built up (formation). Through this process, bone is strengthened and tiny fractures are repaired. Resorption and formation normally are closely coupled in a steady rate of turnover. But after menopause, as estrogen production wanes, resorption outpaces formation, and the turnover rate increases as formation tries to keep up. High bone turnover rates increase the risk for osteoporosis.
To continue reading this article, you must log in.
Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School.
- Research health conditions
- Check your symptoms
- Prepare for a doctor's visit or test
- Find the best treatments and procedures for you
- Explore options for better nutrition and exercise
I'd like to receive access to Harvard Health Online for only $4.99 a month.
Sign Me UpAlready a member? Login ».
Disclaimer:
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.