Sadness touches our lives at different times, but usually comes and goes. Depression, in contrast, often has enormous depth and staying power. It is more than a passing bout of "the blues." Depression can leave you feeling continuously burdened and can squash the joy you once got out of pleasurable activities.
When depression strikes, doctors usually probe what's going on in the mind and brain first. But it's also important to check what's going on in the body, since some medical problems are linked to mood disturbances. In fact, physical illnesses and medication side effects are behind up to 15% of all depression cases.
Depression isn't a one-size-fits-all illness. Instead, it can take many forms. Everyone's experience and treatment for depression is different. Effective treatments include talk therapy, medications, and exercise. Even bright light is used to treat a winter-onset depression known as seasonal affective disorder. Treatment can improve mood, strengthen connections with loved ones, and restore satisfaction in interests and hobbies.
New discoveries are helping improve our understanding of the biology of depression. These advances could pave the way for even more effective treatment with new drugs and devices. Better understanding of the genetics of depression could also usher in an era of personalized treatment.
The most prominent symptom of major depression is a severe and persistent low mood, profound sadness, or a sense of despair. The mood change can sometimes appear as irritability. Or the person suffering major depression may not be able to take pleasure in activities that usually are enjoyable.
Major depression is more than just a passing blue mood, a "bad day" or temporary sadness. The mood changes that occur in major depression are defined as lasting at least two weeks but usually they go on much longer — months or even years.
A variety of symptoms usually accompany the mood change, and the symptoms can vary significantly among different people.
Many people with depression also have anxiety. They may worry more than average about their physical health. They may have excessive conflict in their relationships and may function poorly at work. Sexual functioning may be a problem. People with depression are at more risk for abusing alcohol or other substances.
Depression probably involves changes in the areas of the brain that control mood. Nerve cells may be functioning poorly in certain regions of the brain. Communication between nerve cells or nerve circuits can make it harder for a person to regulate mood. These problems may be affected negatively by hormones. An individual's life experience affects these biological processes. And genetic makeup influences how vulnerable any of us is to breakdowns in these functions.
An episode of depression can be triggered by a stressful life event. But in many cases, depression does not appear to be related to a specific event.
Major depression may occur just once in a person's life or may return repeatedly. Some people who have many episodes of major depression also have a background pattern of a milder depressed mood called dysthymia.
Some people who have episodes of major depression also have episodes of relatively high energy or irritability. They may sleep far less than normal, and may dream up grand plans that could never be carried out. The person may develop thinking that is out of step with reality — psychotic symptoms — such as false beliefs (delusions) or false perceptions (hallucinations). The severe form of this is called "mania" or a manic episode. If a person has milder symptoms of mania and does not lose touch with reality, it is called "hypomania" or a hypomanic episode.
If a woman has a major depressive episode within the first two to three months after giving birth to a baby, it is called postpartum depression. Depression that occurs mainly during the winter months is called seasonal affective disorder, or SAD.
Episodes of depression can occur at any age. Depression is diagnosed in women twice as often as in men. People who have a family member with major depression are more likely to develop depression or drinking problems.
Hair loss is a surprisingly common problem for women, particularly after menopause. This condition is typically treated with a medication such as minoxidil, though other options are available, including hair transplant surgery.
A growing number of studies indicate that yoga may be a beneficial treatment for mental health issues such as anxiety, depression, and post-traumatic stress disorder.
New research has confirmed a link between depression and the menopausal transition, or perimenopause — that time of erratic periods, chaotic hormone fluctuations, disturbed sleep, and, for some, uncomfortable hot flashes. Among the findings: little or no correlation between hormone levels and depression during perimenopause. However, a host of other factors have been implicated.
In 2006, the Harvard Study of Moods and Cycles reported that one in six participants with no history of depression developed depressive symptoms during perimenopause. In addition to hormone fluctuations, researchers have explored the possible influence of psychosocial factors, hot flashes and their impact on sleep, and genetic vulnerabilities. In 2006, the Study of Women's Health Across the Nation identified several genetic mutations that increase the likelihood of perimenopausal depressive symptoms.
In the March/April 2008 issue of the journal Menopause, scientists published data from the Seattle Midlife Women's Health Study. Most of the 302 participating women were in their late 30s or early 40s in the early 1990s, when the 15-year study began.
Seasonal affective disorder is thought to be caused by decreased exposure to sunlight during the winter months. Light therapy helps some people, and the FDA has approved the antidepressant bupropion for treatment as well.
According to the National Comorbidity Survey Replication, only about 40% of people with major depression receive adequate conventional treatment, so it's important to get a better understanding of the other measures depressed patients are taking. A survey of American women indicates that a high proportion of them use alternative and complementary medicines for depression.
Researchers analyzed a national telephone survey of more than 3,000 women, with Mexican Americans, Chinese Americans, and African Americans somewhat over-represented in order to get a picture of ethnic differences. Of these women, 220 said they had been medically diagnosed with depression in the previous year, and 54% of them had used alternative medicine to treat the symptoms. The authors point out that the percentage would have been even higher if they had been able to include depressed women who never received a medical diagnosis.
The most popular alternatives were manual therapies, including chiropractic, massage, and acupressure, used by 26%; medicinal herbs and teas, used by 20%; and vitamins and nutritional supplements, used by 16%. Other unconventional remedies were yoga, meditation, tai chi, Chinese medicine, Ayurveda, and Native American healing.
Depression can often develop as a result of a heart attack or cardiac surgery, and has more serious effects on heart health and overall health than depression that was present before a heart attack.
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Surviving a heart attack is cause for celebration. It's also a trigger for depression. Up to half of heart attack survivors get the blues, and many go on to develop clinical depression.
Early experiences with antidepressants weren't that promising because older tricyclic drugs such as clomipramine and nortriptyline sometimes threw off heart rhythms and further endangered the heart. This made doctors leery about recommending antidepressants, even when selective serotonin reuptake inhibitors (SSRIs) such as Prozac (fluoxetine), and Zoloft (sertraline), and others came along.
However, a small study published in 2002, dubbed SADHART, suggested that Zoloft could safely treat depression after a heart attack and might be good for the heart to boot. And an analysis of a larger trial, called ENRICHD, lends support to the notion that treating post-heart-attack depression with an SSRI may also reduce the chances of having, or dying from, a heart attack.