In Brief: Treating depression in adolescents

Published: January, 2010

Long-term outcomes of the Treatment for Adolescents with Depression Study (TADS) not only confirm earlier findings that combining medication and cognitive behavioral therapy (CBT) offers the quickest and best chance of recovery to depressed adolescents, but that either therapy alone is also effective.

The study — funded by the National Institute of Mental Health — is one of the most comprehensive done to date on this issue. Investigators at 13 medical centers across the United States enrolled 327 patients ages 12 to 17, all diagnosed with major depression. The youths were randomly assigned to treatment with fluoxetine (Prozac), CBT, or both.

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