In Brief: Off-label drug use
Off-label drug use
A study of Medicaid recipients in Georgia shows that antidepressants, anticonvulsants, and antipsychotic drugs are widely prescribed off-label — that is, in the treatment of disorders for which they do not have FDA approval.
The analysis indicates that in the year 2001, 75% of adult Medicaid patients receiving antidepressants, 80% of those receiving anticonvulsants, and 64% of those receiving antipsychotic drugs were given at least one prescription for these medications off-label. The proportion of off-label prescriptions was especially high for the anticonvulsant gabapentin (98%), the antidepressant amitriptyline (81%), and the sleeping pill and anti-anxiety drug lorazepam (89%).