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Harvard Mental Health Letter

Cytochrome P450 enzymes and psychiatric drugs

Published: February, 2009

How a patient's genetic profile and other medications can alter drug response.

The American Journal of Psychiatry published an article describing the hypothetical case of a woman who sought treatment for depression while taking tamoxifen, a drug often prescribed to reduce the likelihood of breast cancer recurrence. The case was intended to illustrate the impact that the liver's cytochrome P450 enzymes can have on psychiatric drug choice, especially when patients are taking multiple medications.

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Daily Health Tip

Try the tree pose

To build concentration and balance, try doing the tree pose: Stand with your feet directly under your hips, feet parallel. Lift your right foot and rest it on the inside of your left leg, under your knee. Clasp your hands together in front of your heart. Keep your gaze forward and take up to six easy breaths. Then repeat, this time standing on your right leg and lifting your left. If your balance is shaky, rest your hands on a chair in front of you.

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