Getting up at night to use the bathroom is often thought of as a problem mainly for older men. Not so—two in three women over age 40 wake up at least once each night because of a full bladder. And nearly half of them make two or more nighttime trips to the bathroom. Factors that increased the likelihood that a woman woke at night to urinate included older age, having had a hysterectomy, having hot flashes, and using vaginal estrogen. Many of the women had no other urinary problems, such as an overactive bladder or leaking urine when coughing, and many weren’t especially bothered by having to get up at night to urinate. Getting up once or more each night to urinate may not be “bothersome,” but it can still cause problems. It can interfere with sleep. It can also lead to falls and injury.