Cardiologists from around the world have gathered in Washington, DC, for the 65th annual meeting of the American College of Cardiology in Washington, DC. During the opening lecture, Dr. Gary Gibbons, director of the National Heart, Lung, and Blood Institute, talked about the “challenge of success.” What does that mean? Since 1950, death rates from cardiovascular disease have plummeted by 70%, thanks to two major trends. One is the decline in smoking and improvements in cholesterol and blood pressure. The other is the boom in new therapies, including better medications, surgeries, and high-tech procedures to repair an array of heart problems. The challenge today is finding a new drug or procedure that raises this already high bar. Here’s a summary of four reports, two negative and two positive, of studies on new treatments for heart disease.