Brain imaging techniques for Alzheimer's disease

In many ways, Alzheimer's disease is the biological version of a slow-motion train wreck. The disease process begins years before symptoms are evident. There is no cure, and current treatments alleviate symptoms temporarily at best. As they evaluate new drug therapies, researchers are using various brain imaging techniques to better identify the patients who are most likely to benefit from treatment -- those at the earliest stages of the Alzheimer's disease process. In this slide show, we show what these brain scans look like and what challenges remain. (Locked) More »

References for "Cytochrome P450 enzymes and psychiatric drugs"

Bondy B, et al. "Pharmacogenetics of Antipsychotics: Useful for the Clinician?" Current Opinion in Psychiatry (March 2007): Vol. 20, No. 2, pp. 126–30. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17278909 De Leon J, et al. "Clinical Guidelines for Psychiatrists for the Use of Pharmacogenetic Testing for CYP450 2D6 and CYP450 2C19," Psychosomatics (Jan.–Feb. 2006): Vol. 47, No. 1, pp. 75–85. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16384813 Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. "Recommendations from the EGAPP Working Group: Testing for Cytochrome P450 Polymorphisms in Adults with Nonpsychotic Depression Treated with Selective Serotonin Reuptake Inhibitors," Genetics in Medicine (Dec. 2007): Vol. 9, No. 12, pp. 819–25. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18091431 (Locked) More »

References for "Failed efforts to thwart Alzheimer's disease raise questions"

Aisen PS, et al. "High-dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Controlled Trial," Journal of the American Medical Association (Oct. 15, 2008): Vol. 300, No. 15, pp. 1774–83. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18854539 Atri A, et al. "Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease," Alzheimer Disease and Associated Disorders (July–Sept., 2008): Vol. 22, No. 3, pp. 209–21. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18580597 Arvanitakis Z, et al. "Statins, Incident Alzheimer Disease, Change in Cognitive Function, and Neuropathology," Neurology (May 6, 2008): Vol. 70, No. 19, pt. 2, pp. 1795–802. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18199831 (Locked) More »

References for "When children with bipolar disorder grow up"

Findling RL, et al. "Rapid, Continuous Cycling and Psychiatric Comorbidity in Pediatric Bipolar I Disorder," Bipolar Disorders (Aug. 2001): Vol. 3, No. 4, pp. 202–10. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11552959 Geller B, et al. "Child Bipolar I Disorder: Prospective Continuity with Adult Bipolar I Disorder; Characteristics of Second and Third Episodes; Predictors of 8-Year Outcome," Archives of General Psychiatry (Oct. 2008): Vol. 65, No. 10, pp. 1125–33. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18838629 Geller B, et al. "Proposed Definitions of Bipolar I Disorder Episodes and Daily Rapid Cycling Phenomena in Preschoolers, School-Aged Children, Adolescents, and Adults," Journal of Child and Adolescent Psychopharmacology (April 2007): Vol. 17, No. 2, pp. 217–22. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17489716 (Locked) More »

Cytochrome P450 enzymes and psychiatric drugs

Some people metabolize certain psychiatric medications too quickly, while others do so too slowly. Factors that can affect this include ethnicity, medical history, other medications being taken, diet, and lifestyle. (Locked) More »

When children with bipolar disorder grow up

A study of children diagnosed with bipolar disorder, who were assessed periodically over several years, found that manic episodes persisted into adulthood for 44% of the participants, and that about one third had developed substance abuse problems. (Locked) More »

In brief: Improving outcomes for opioid-addicted youth

Young people with an opioid addiction who received a more prolonged treatment regimen during a study were less likely to relapse, but after the study's end they were almost as likely to use again as the group receiving less intensive treatment. (Locked) More »