Harvard Mental Health Letter

Second-step treatments for adolescent depression

The TORDIA study suggests options when initial drug treatment fails.

After six months of treatment with either an antidepressant or psychotherapy, about 60% of adolescents newly diagnosed with major depression attain remission. The Treatment of Resistant Depression in Adolescents (TORDIA) study was designed to determine how best to treat those youths who have not obtained adequate relief after one medication.

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