Harvard Men's Health Watch

On call: Prostatic intraepithelial neoplasia

Q. My prostate is not enlarged and I have no urinary tract symptoms, but I've had three prostate biopsies over the past four years because my PSA has gone from 3.2 to 4.8. The first two biopsies were normal, but the new one found "PIN" but no cancer.

Please explain "PIN" and tell me what it means for me. I'm 59 years old, and except for my prostate, I don't have a worry in the world.

A. It's easier to explain PIN than to say what it means for you. Although doctors have been studying prostatic intraepithelial neoplasia (PIN) for about three decades, they still have as many questions as answers.

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