Harvard Mental Health Letter

Revisiting the CATIE schizophrenia study

Although questions remain, some clinical guidance has emerged.

The ongoing U.S. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study is the largest and longest independent investigation into schizophrenia medications ever conducted. But so far it has raised as many questions as it has answered.

CATIE was intended as a practical, real-world test of treatments for chronic schizophrenia. The goal was to answer three questions: how four second-generation antipsychotics compare to one another; how they compare to a representative first-generation antipsychotic; and whether the second-generation drugs are cost-effective.

To continue reading this article, you must login.
  • Research health conditions
  • Check your symptoms
  • Prepare for a doctor's visit or test
  • Find the best treatments and procedures for you
  • Explore options for better nutrition and exercise
Learn more about the many benefits and features of joining Harvard Health Online »