For people with heart disease, naproxen may be the best choice
for easing pain.
Choices abound for easing the nagging pain of arthritis, a sore
shoulder, bad back, or other ongoing problems. For this sort of
long-term pain relief, most people reach for an over-the-counter
painkiller like aspirin, acetaminophen (Tylenol, generic),
ibuprofen (Motrin, generic), or naproxen (Aleve, generic). Some
rely on prescription drugs such as celecoxib (Celebrex). A study
supports the idea that one of these — naproxen — is easiest on
Pain relievers in the class known as nonsteroidal
anti-inflammatory drugs (NSAIDs) have different
effects on the heart, blood vessels, blood, and
Among over-the-counter NSAIDs, naproxen appears to
have a beneficial — or no — effect on the heart,
while ibuprofen may increase the risk of a heart
attack or stroke, possibly by interfering with the
action of aspirin.
If you take both aspirin and ibuprofen, take the
aspirin first each day and wait 30 minutes or so
before taking ibuprofen.
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