Statins can reduce the risk of heart attacks and other major clinical manifestations of coronary artery disease (CAD) by up to 37%, with the greatest benefit going to men at the highest risk. And since heart disease is America's leading cause of death, it's no wonder that the seven statin drugs are the best-selling prescription medications in the United States. This article examines the noncoronary effects of statins, starting with the vascular and cardiac effects that are most closely related to cholesterol and coronary artery disease.
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