Safety of over-the-counter sleeping pills
Many people wonder about over-the-counter (OTC) medications like
Tylenol PM that combine a pain reliever and a sleep aid. These pills
help many get to sleep, but is it a good idea to keep on taking them?
The sleep-inducing ingredient in Tylenol PM is diphenhydramine, an antihistamine.
People take antihistamines for hay fever or cold symptoms, but doctors
have known for a long time that they also make people drowsy. Other nighttime
pain relievers (Alka-Seltzer PM, Excedrin PM) contain diphenhydramine,
and it’s the only active ingredient in OTC sleeping pills like
Sominex and Simply Sleep. Sominex and the allergy-relief version of Benadryl
have exactly the same active ingredient: 25 milligrams of diphenhydramine.
Dr. David White, director of the Sleep Disorders Program at Harvard-affiliated
Brigham and Women’s Hospital, is not a fan of the antihistamines.
He says they leave many people feeling groggy and tired rather than rested.
And true to their anti–hay fever effects, they dry out the nose
For people who have a hard time falling asleep, Dr. White prescribes
either zolpidem (Ambien) or zaleplon (Sonata). For those who have trouble
staying asleep, there are medications that stay in your system longer.
The main choices have been trazodone (Desyrel), a sedating antidepressant,
or one of the benzodiazepines (Ativan, Restoril, others). But trazodone
doesn’t work for many people and hasn’t been well studied.
The benzodiazepines cause daytime drowsiness and withdrawal symptoms
if they’re taken for a long time.
In December 2004, the FDA approved a new long-acting medication, eszopiclone
(Lunesta). You aren’t supposed to take the other sleeping pills
for more than a few weeks. The FDA didn’t set any such time restrictions
on Lunesta, so it could become the first medication approved as a sleeping
pill that people can take indefinitely.
August 2005 Update
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