Diarrheal Diseases and
Manufacturer Voluntarily Withdraws Lotronex
Lotronex (alosetron) is a prescription medication used to treat diarrhea-predominant
irritable bowel syndrome in women. Last month, the Food and Drug Administration
issued important safety warnings for the use of this drug based upon
reports of intestinal damage due to impaired blood flow to the intestine
(ischemic colitis) and complications of severe constipation (bowel obstruction
and rupture) in patients on Lotronex. (See the Family Health Guide Online
update on Lotronex).
On November 30, the manufacturer (Galaxo Wellcome) informed the FDA that
it will voluntarily remove this drug from the market. Any patient currently
taking Lotronex should contact her physician to discuss other treatment
options. For more information, please visit the Center for Drug Evaluation
and Research Web page on Lotronex or
call 888-INFO-FDA (888-463-6332).
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