Bone Marrow Biopsy
View other tests
What is the test?
Doctors can diagnose
many problems that cause anemia, some infections, and some kinds
of leukemia or lymphoma cancers by examining a sample of your
bone marrow (the tissue where blood cells are made). A bone marrow
biopsy is the procedure to collect such a sample. It is done
using a large needle inserted through the outside surface of
a bone and into the middle of the bone, where the marrow is.
Back to top >
How do I prepare
for the test?
You will need to sign
a consent form giving your doctor permission to perform this
test. Because you will probably receive some pain medicines or
anti-anxiety medications that can make you drowsy, you will need
to arrange a ride home.
Tell your doctor if
you have ever had an allergic reaction to lidocaine or the numbing
medicine used at the dentist's office. Also talk with your doctor
before the test if you are taking insulin, or if you take aspirin,
nonsteroidal anti-inflammatory drugs, or other medicines that
affect blood clotting. It may be necessary to stop or adjust
the dose of these medicines before your test. Most people need
to have a blood test done some time before the procedure to make
sure they are not at high risk for bleeding complications.
Usually you will be
told not to eat anything after midnight on the night before the
test. This is in case you experience nausea from the anti-anxiety
medicines.
Back to top >
What happens
when the test is performed?
Most patients have this
test done by a hematologist in a clinic procedure area. You wear
a hospital gown during the procedure. A sedative may be injected
at this time. (If you are prescribed a sedative in pill form,
you will be instructed to take it ahead of time.)
Most patients have bone
marrow sampled from the pelvis. You lie on your stomach and the
doctor feels the bones at the top of your buttock. An area on
your buttock is cleaned with soap. A local anesthetic is injected
to numb the skin and the tissue underneath the skin in the sampling
area. This causes some very brief stinging.
A small cut is made
in the skin to allow the biopsy needle to be placed through the
skin. This needle is about half as wide as a pencil and has a
handle on one end that your doctor holds while he or she moves
it through your bone. The biopsy needle is moved through the
bone with a twisting motion, as a corkscrew would be moved through
a cork. When the needle has passed through the top layer of bone,
your doctor uses a syringe to pull a liquid sample of your bone
marrow cells through the needle. For most patients, the suction
used in this liquid collection causes a pain in the buttock for
a few seconds; this is why pain medicine is usually given in
preparation for the biopsy.
After taking the liquid
sample, the doctor carefully moves the needle a little bit further
into the bone marrow to collect a second sample of marrow called
a core biopsy. This core biopsy is a small solid piece of bone
marrow, with not just the liquid and cells but also the fat and
bone fibers that hold them together. After the needle is pulled
out, this solid sample can be pushed out of the needle with a
wire so that it can be examined under a microscope. Pressure
is applied to your buttock at the biopsy location for a few minutes,
until you are not at risk of bleeding. A bandage is placed on
your buttock.
Back to top >
What risks are
there from the test?
Risks are minimal. Having
a sample taken is not harmful for your bone or bone marrow. Injury
of nearby tissue from the biopsy is very uncommon. You might
have some buttock soreness for a few days, and you may have some
bruising at the biopsy site. A few individuals have an allergy
or a side effect from the pain medicine or anti-anxiety medicine.
Back to top >
Must
I do anything special after the test is over?
You will feel sleepy
from the medicines used to reduce pain and anxiety. Once these
medicines have worn off (a few hours after the test), you can
return to normal activities, but you should not drive or drink
alcohol for the rest of the day.
Back to top >
How
long is it before the result of the test is known?
The samples taken need
to be treated in the laboratory and prepared on slides that can
be seen under the microscope. Some parts of your bone marrow
biopsy report may be available within a day, but some tests require
special stains or tests that can take longer, in some cases up
to one week.
Back to top >
View other tests |