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December
2002
Medications
for postmenopausal osteoporosis prevention
Risk of osteoporosis increases after menopause, when levels of estrogen
— which helps preserve bone density — drop. Until recently,
most doctors recommended long-term hormone replacement therapy (HRT)
to treat postmenopausal women who need medication to prevent bone loss.
But things changed after results from a large trial on a common HRT drug
showed that estrogen plus progestin (as the medication Prempro) did more
harm than good. An increased risk for breast cancer and cardiovascular
events outweighed the benefits of less colorectal cancer and fewer fractures.
(See the Update from July 2002 for more information on the trial.)
Health experts now encourage most women who have been taking long-term
HRT for osteoporosis prevention to consider an alternative. Fortunately
there are several options. Each of the FDA-approved treatments (see chart)
has potential benefits and risks that women and their doctors should
weigh before making a decision. Even with HRT’s proven risks, it
may still be a good choice for certain women — especially in lower
doses, which recent data have shown to have bone benefits comparable
to higher, standard doses.
Approved medications
for osteoporosis prevention |
Medication |
How to take it |
Bone benefits |
Side effects |
Comments |
Alendronate (Fosamax) |
Orally, once daily in the morning or as a larger
dose once a week; take with 6–8 ounces of water and stay
upright for 30 minutes. |
Increases bone density at the spine and hip; reduces
spinal and hip fracture risk. Side effects uncommon. |
Heartburn, nausea, inflammation of the esophagus,
muscle pain. |
Interferes with cells that break down bone. Well-tolerated
when taken properly. |
Risedronate (Actonel) |
Orally, once daily in the morning or as a larger
dose once a week; take with 6–8 ounces of water and stay
upright for 30 minutes. |
Increases bone density at the spine and hip; reduces
spinal and hip fracture risk. Side effects uncommon. |
Abdominal pain, nausea, constipation, joint pain. |
Interferes with cells that break down bone. Well-tolerated
when taken properly. |
Raloxifene (Evista) |
Orally, once daily, any time. |
Increases bone density (but less so than alendronate
or risedronate); reduces spinal fracture risk. Side effects uncommon. |
Hot flashes, leg cramps, deep-vein blood clots. |
Acts like estrogen in bone but is an anti-estrogen
in breast tissue; may reduce breast cancer risk. |
Estrogen (Premarin, Estrace, other brands) |
Orally, once daily, any time; or weekly by skin
patch. |
Increases bone density; some evidence for fracture
reduction. |
Increases the risk for breast cancer (after 4–5
years) and cardiovascular events when combined with a progestin
(as Prempro) and taken orally. |
May be recommended if other medications are not
tolerable or menopausal symptoms persist. |
Sources: Boosting Bone Strength: A
Guide to Preventing and Treating Osteoporosis, Harvard
Health Publications, Boston, 2000; Managing Osteoporosis,
Part 3: Prevention and Treatment of Postmenopausal Osteoporosis, American
Medical Association, 2000; Osteoporosis: Guide to Prevention,
Diagnosis, and Treatment, Brigham and Women’s Hospital,
Boston, 2002 |
December 2002 Update
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Manual vs. Powered
Toothbrushes
Good news — you don’t have to buy an electric toothbrush
to get clean teeth. As more power toothbrushes hit the store shelves,
you may feel pressure to buy one. More expensive is better, right? Not
necessarily. According to the American Dental Association (ADA), a manual
toothbrush can clean teeth just as well as a power toothbrush. The secret
lies in how the toothbrush is used.
By following the tips below you can ensure a good brushing:
- Brush the inner, outer, and chewing surfaces of the teeth with
short (teeth-wide), back and forth strokes.
- Place the brush at a 45-degree angle against your gums when brushing
along the gum line.
- To clean the inside surfaces of the front teeth, use gentle up and
down strokes with the tip of the toothbrush.
- Use a soft touch. Vigorous brushing won’t get more plaque off
and can irritate your gums.
- A set time is not necessary; just make sure you are cleaning all
the surfaces of your teeth thoroughly.
- Be sure to replace your toothbrush once the bristles have become
frayed or every three to four months.
An electric toothbrush may be the right choice for you, however. People
with arthritis or other conditions that impair motor skills may need
the relative ease of a powered toothbrush to do an adequate job of brushing
their teeth. You should talk with your dentist or hygienist to determine
which type of toothbrush is best for you.
When purchasing a toothbrush, look for the ADA Seal of Acceptance. To
take part in this voluntary program, dental product manufacturers must
prove their product meets ADA criteria for effectiveness and safety.
Also, scientific studies must support the claims of any packaging or
advertising of products bearing the ADA Seal.
December 2002 Update
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Botox injections
With the recent nod of approval from the Food and Drug Administration
(FDA), the popularity of Botox injections has surged. Spas, shopping
malls, walk-in clinics and even parties advertise the availability of
this age-defying treatment. Even before FDA approval, the use of Botox
was on the rise, increasing 61% between 2000 and 2001, according to the
American Society of Plastic Surgeons.
Botox, the trade name for botulinum toxin type A, is used to lessen
the telltale signs of aging by softening frown lines on the forehead
and brow, crow’s feet at the corners of the eye, and other wrinkles.
But what is this toxin, how does it work, and who should be administering
the procedure?
Botulinum toxin type A is one of several proteins secreted by the bacterium Clostridium
botulinum. These proteins are neurotoxins; they attack nerve cells
and paralyze the affected muscles. Ingestion of botulinum toxins causes
the infamous food poisoning botulism. But when the purified form of
botulinum toxin type A is injected into the muscles below the skin
in very low doses, the result is a reduction in wrinkling.
As we age, our skin becomes less elastic and wrinkles remain even when
the muscles controlling the skin are relaxed. Botulinum toxin lessens
wrinkles by attaching itself to nerve endings in the muscle and preventing
the release of the neurotransmitter acetylcholine. This blocks the nerve
signals transmitted from the brain to the muscles and paralyzes or weakens
the muscle controlling the wrinkled skin. The result is the smoothing
out of the skin from disuse — if it can’t move, it can’t
wrinkle.
Botox injections are done in a quick and easy procedure lasting less
than 30 minutes. The toxin takes effect within a week. The results are
temporary, however, so retreatment is necessary within three to six months.
Botox may be used in conjunction with or as an alternative to other facial
skin rejuvenation procedures such as chemical peels or laser skin resurfacing.
When performed by an experienced physician, the most common adverse side
effects of the procedure include headache, respiratory infection, flu
syndrome, and nausea.
With the potential results and relative ease, it is easy to forget Botox
is a prescription drug and not just an injection. However, the results
of the procedure largely depend on the injector’s knowledge of
the complex muscular anatomy of the face, the effects of the drug, and
the principles of aesthetics. Each face must be treated differently.
An inexperienced or careless injector may introduce the toxin into parts
of the face that result in droopy eyelids or brows. Injections in several
parts of the face at the same time can result in excessive paralysis,
leading to a
"frozen" or unexpressive look that may take a few months to
disappear.
For the best results, anyone considering this procedure should find
a dermatologist or dermatologic surgeon with training and experience
in the technique. The physician should also spend adequate time with
the patient discussing the desired results and the patient’s medical
history. A patient must understand the risks, benefits, alternatives,
and reasoning for the procedure. The injections should be performed in
an appropriate setting such as a medical office with medical personnel
and equipment ready to deal with potential complications.
The injections are on the pricey side, though, costing an average of
$400.
December 2002 Update
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