Paget's Disease of Bone

What Is It?

Bones in your body continuously break down and form again in a natural and tightly balanced process called bone remodeling. This bone remodeling also occurs in response to stress or injury placed on the bone. For example, weight-bearing exercise leads to increased bone formation.

In Paget's disease, more bone breaks down than usual and more new bone forms than usual. These changes in the bone can lead to bone enlargement and deformity. The new bone growth tends to be softer and more fragile than normal bone, and can develop in a haphazard pattern. Because of this, the bone can fracture. The long bones, especially the legs, tend to bow, and the skull may enlarge, particularly over the forehead.

Paget's disease is the second most common bone disorder in people over 50, after osteoporosis. It is rarely diagnosed in young adults.

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