What Is It?
Malaria is an infection caused by single-celled parasites that enter the blood through the bite of an Anopheles mosquito. These parasites, called plasmodia, belong to at least five species. Most human infections are caused by either Plasmodium falciparum or Plasmodium vivax.
Plasmodium parasites spend several parts of their life cycle inside humans and another part inside mosquitoes. During the human part of their life cycle, Plasmodium parasites infect and multiply inside liver cells and red blood cells.
Some infected blood cells burst because of the multiplying parasites inside. Many more infected red blood cells are broken down by your spleen or liver, which filter out and remove damaged or aging red blood cells from circulation. Both Plasmodium parasites in the bloodstream and irritants that are released from broken red blood cells cause malaria symptoms.