Harvard Women's Health Watch

Major depression more likely during perimenopause than during premenopause

Perimenopause begins several years before menopause (the end of menstruation) and ends a year after the last menstrual period. During this transition, ovarian hormones are in flux, resulting in irregular periods and sometimes vasomotor symptoms (hot flashes and night sweats). In a study, approximately one-third of women in perimenopause had at least one episode of major depression.
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