Fifth disease, also known as erythema infectiosum, is a common viral infection among school-aged children. It is caused by parvovirus B19, which spreads through direct contact with fluids or mucus from the nose or mouth of an infected person. Fifth disease causes a bright red "slapped cheek" rash that doesn't appear until an infected person is no longer contagious. Fifth disease usually is a mild illness, and some people who are infected may never realize they have it.
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