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For borderline underactive thyroid, drug therapy isn’t always necessary

Posted By Heidi Godman On October 9, 2013

I’m always amazed to see just how many problems a slowdown in the output of the thyroid gland can cause: extreme fatigue, intolerance to cold, weight gain, dry skin, and dry hair, to name a few. Millions of Americans—and I count myself among them—have an underactive thyroid, a condition known as hypothyroidism. That means this butterfly-shaped gland doesn’t produce enough thyroid hormone to regulate metabolism, causing many body functions to become sluggish. The resulting symptoms are no picnic, but they’re usually ones that can be controlled with a daily dose of synthetic thyroid hormone called levothyroxine (generic, Synthroid, Tirosint, others).

Who actually benefits from taking levothyroxine is being called into question. New evidence suggests that many people may be taking this medication unnecessarily, to the point of overtreatment. In a study published this week in JAMA Internal Medicine, researchers in the United Kingdom determined that levothyroxine is widely prescribed for people with borderline hypothyroidism, and often without much benefit. The researchers point out that the overtreatment may be due to inadequate monitoring of thyroid hormone levels, as well as physicians prescribing the drug to treat symptoms that aren’t actually due to hypothyroidism.

Endocrinologist Dr. Jeffrey Garber, an associate professor of medicine at Harvard Medical School, agrees with the findings. He’s an internationally respected authority on thyroid disease, and author of The Harvard Medical School Guide to Overcoming Thyroid Problems. He says a number of factors may be contributing to the increase in treatment of mild hypothyroidism. “Greater patient and physician attention to thyroid status may be prompting more testing and leading to more diagnoses,” he says. Plus, he points out, the threshold of what’s considered a normal thyroid range was lowered in 2002, and that lower number is what labs use today when they look at thyroid hormones in the blood.

Maybe that’s why prescriptions of levothyroxine increased in the U.S. from about 50 million in 2006 to about 70 million in 2010. Researchers found a similar increase in England and Wales, with prescriptions jumping from 17 million in 2006 to 23 million in 2010.

What’s wrong with giving people who have a borderline underactive thyroid a little something to make them feel better. Well, it’s a pretty risky business. They run the risk of experiencing side effects from taking levothyroxine, which include irregular heart rhythms, insomnia, and loss of bone density, without reaping any benefit from it.

Dr. Garber is hoping that clinical practice guidelines that came out last year (for which he was the lead author) will make a difference in diagnosis. The guidelines come from a task force representing the American Thyroid Association and the American Association of Clinical Endocrinologists.

There are many nuances to the guidelines, but here are two of the most important recommendations for diagnosis that warrants treatment:

Best test. The best way to check for hypothyroidism is to look at the level of thyroid stimulating hormone (TSH) in the blood. That’s the hormone the pituitary gland sends out to tell the thyroid how much thyroid hormone to release. If the thyroid is underactive, the pituitary gland will tell the thyroid to work harder, and it does that by sending out more TSH. So the higher the TSH level, the lower the thyroid activity. A normal TSH value is under 4.0 milli-international units per liter (mIU/L). When the TSH level is above 10 mIU/L, there’s uniform agreement that treatment with levothyroxine is appropriate.

Borderline results. If the TSH level is between 4mIU/L and 10mIU/L, treatment may still be warranted in various situations:

  • if the levels of actual thyroid hormones in the blood—known as thyroxine (T4) and triiodothyronine (T3)—are abnormal
  • if the bloodstream contains anti-thyroid antibodies that attack the thyroid. These antibodies would indicate a hypothyroid condition called Hashimoto’s disease, in which the immune system mistakenly attacks the thyroid.
  • if there is evidence of heart disease or risk for it.

What should you do if you have borderline low thyroid levels that cause uncomfortable symptoms but don’t meet the guidelines for treatment? “Use thyroid hormone for a brief period of time,” recommends Dr. Gerber. “If you feel better, you can continue with treatment. If not, then stop.”

All treatment for hypothyroidism, even borderline cases, must be individualized and monitored carefully by a physician. That requires measuring TSH four to eight weeks after starting treatment or changing a dose, another TSH test after six months, then every 12 months.

Because hypothyroidism can be a tricky condition to diagnose and manage, it’s no picnic for doctor or patient. But if you’re at the party together, you have a better chance of feeling better without being treated unnecessarily.

Related Information: Thyroid Disease: Understanding hypothyroidism and…

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